期刊文献+

慢性阻塞性肺疾病患者呼出气冷凝液中髓过氧化物酶检测的临床意义

Clinical Significance of Myeloperoxidase Detection of Exhaled Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease(COPD)
下载PDF
导出
摘要 目的探讨慢性阻塞性肺疾病(COPD)患者呼出气冷凝液(EBC)中髓过氧化物酶(MPO)的浓度改变及临床意义。方法收集49例COPD患者、18例健康体检者的EBC,用酶免疫法测定EBC中MPO浓度。结果 COPD组MPO浓度显著高于对照组(P<0.05);COPD组EBC中MPO浓度与患者FEV1占预计值%、PEF呈正相关(均P<0.05)。结论 COPD患者EBC中的MPO浓度能反映炎症和氧化应激程度,监测EBC中的MPO浓度可作为一种较好的评价COPD病情的生物学指标。 Objective To discuss the change and clinical significance of myeloperoxidase (MPO) in exhaled breath condensate (EBC) of patients with chronic obstructive pulmonary disease (COPD). Methods EBC of 49 patients with COPD and 18 healthy controls were collected, and the concentrations of MPO in EBC were determined by enzyme-linked immunosorbent assay. Results The concentration of MPO in COPD group was significantly higher than that of control group (P〈0.05). The MPO concentration of COPD group was positively correlated to spirometric parameters, P 〈0.05. Conclusions The MPO concentration in EBC of COPD patients can reflect the degree of inflammation and oxidative stress. Monitoring of EBC MPO concentration can be used as a better evaluation index of COPD disease.
出处 《临床医学工程》 2014年第8期991-992,共2页 Clinical Medicine & Engineering
关键词 慢性阻塞性肺疾病 呼出气冷凝液 髓过氧化物酶 Chronic obstructive pulmonary disease (COPD) Exhaled breath condensate (EBC) Myeloperoxidase
  • 引文网络
  • 相关文献

参考文献14

  • 1慢性阻塞性肺疾病诊治指南(2007年修订版)[J].中华结核和呼吸杂志,2007,30(1):8-17. 被引量:8240
  • 2钟南山.慢性阻塞性肺疾病在中国[J].中国实用内科杂志,2011,31(5):321-322. 被引量:184
  • 3Hoffmeyer F, Harth V, Bunger J, et al. Leukotriene B4, 8-iso-prostaglandin F2 alpha, and pH in exhaled breath condensate from asymptomatie smokers [J] . J Physlal Pharmacal, 2009, 60 (Suppl 5) : 57-60.
  • 4Risby TH. Further discussion on breath condensate analysis [J] . Am JRespir Crit Care Med, 2003, 167 (10) : 1301-1302.
  • 5Effros RM, Su J, Casaburi R, et al. Utility of exhaled breath conden- sates in chronic obstructive puhnonary disease: a critical review [J] . Curt Opin Pulm Med, 2005, 11 (2) : 135-139.
  • 6Horv6th I, Hunt J, Barnes PJ, et al. Exhaled breath condensate: method- alogical recommendations and unresalved questions [J] . Eur Respir J, 2005, 26 (3) : 523-548.
  • 7Montuschi P. Analysis of exhaled breath condensate in respiratory medicine: methodalogical aspects and potential clinical applications [J] . TherAdv Respir Dis, 2007, 1 (1) : 5-23.
  • 8Gessner C, Dihazi H, Brettschneider S, et al. Presence of cytokeratins in exhaled breath condensate of mechanical ventilated patients [J] . Respir Med, 2008, 102 (2) : 299-306.
  • 9Kharitonov SA, Barnes PJ. Biomarkers of some pulmonary diseases in exhaled breath [J] . Biomarkers, 2002, 7 (1) : 1-32.
  • 10汤红英,郑玉建,吴顺华.髓过氧化物酶相关疾病的研究进展[J].新疆医科大学学报,2009,32(3):255-258. 被引量:7

二级参考文献33

共引文献8398

;
使用帮助 返回顶部