有氧运动与干细胞动员的心肌细胞增殖研究进展

Research Advance on Cardiomyocyte Proliferation Induced by Aerobic Exercise and Stem Cell Mobilization

适宜运动是防治心脏疾病的有效方式,其作用机制尚未完全阐明,安全有效的运动处方需要系统研究。运动可使正常心肌细胞发生生理性肥大与增殖以及多种细胞因子的分泌和干细胞的有效动员,促进心肌细胞增殖分化。成体心肌细胞增殖的来源包括存活的心肌细胞、心肌干/祖细胞以及外周的骨髓间充质干细胞等。干细胞的动员、趋化归巢并分化为心肌细胞是心肌损伤修复的细胞基础。本文从心肌细胞增殖潜力、心肌梗死(MI)的干细胞治疗和运动促进MI心肌细胞增殖等三个方面综述运动促进干细胞动员,诱导内源性心肌细胞再生对MI心肌修复和心功能改善的可能机制、存在问题及相关研究进展。

Appropriate exercise is the effective way for the prevention and treatment of heart diseases. Its mechanism has not been completely elucidated,and the safe and effective exercise prescription needs to be studied systematically. Exercises give rise to secretion of various cell factors,effective stem cell mobilization,physiological hypertrophy and differentiation and proliferation of cardiomyocytes. The cell sources of adult cardiomyocyte proliferation included viable cardiomyocytes,cardiac stem /progenitor cells,bone marrow stem cells,peripheral stem cells. Stem cell mobilization,homing and differentiation are the cellular basis of myocardial repair after injury. From the potential of cardiomyocyte proliferation,stem cell therapy after myocardial infarction and cardiac myocyte proliferation induced by exercise,this review focused on the stem cells mobilization promoted by aerobic exercise,the possible mechanism of cardiac repair and functional amelioration induced by the differentiation of those stem cells after myocardial infarction,the problems remained to be further studied and correlative research progress.