摘要
目的探讨丁苯酞注射液对急性脑梗死患者神经功能及脑血管储备能力的影响。方法 108例急性脑梗死患者随机分为2组,观察组62例,对照组46例。对照组采用常规治疗,观察组在常规治疗的基础上加用丁苯酞注射液。根据NIHSS评分评价治疗前后患者的神经功能。采用TCD测定治疗前后2组患者的脑血管储备功能。结果观察组基本痊愈28例,显效16例,有效12例,无效4例,总有效率93.5%;对照组基本痊愈13例,显效11例,有效15例,无效7例,总有效率84.8%。观察组总有效率明显高于对照组(P<0.05)。治疗后2组患者NIHSS评分均明显降低(P<0.01),与对照组治疗后比较,观察组降低更明显(P<0.05)。大脑中动脉平均血流量(MCV)增加值治疗后均升高,且观察组升高更明显(P<0.05);2组治疗后脉动指数(PI)均明显降低,且观察组降低更明显(P<0.05);2组治疗后脑血管储备功能(CVR)均明显升高,且观察组升高更明显(P<0.05)。结论丁苯酞注射液可明显提高急性脑梗死患者神经功能及脑血管储备能力。
Objective To study the effect of butylphthalide Injection on neurological function and cerebrovascular reserve capacity in patients with acute cerebral infarction. Methods 108 patients with acute cerebral infarction were randomly divided into two groups, the observation group(62 cases) and the control group(46 cases). The patients in the control group were trea- ted with the conventional method, while the patients in the observation group were treated with the conventional method plus butylphthalide injection. According to NIHSS score, patients" neurological function were evaluated before and after treatment. TCD was used to measure cerebrovascular reserve capacity of patients in the two groups before and after treatment. Results 28 cases in the observation group recovered, 16 cases was markedly effective, 12 cases effective, 4 cases non-effective, the total effective rate was 93.5~/oo. 13 cases in the control group recovered, 11 cases was markedly effective , 15 cases effective, 7 cases non--effective, the total effective rate was 84.8%. The total efficiency of the observation group was significantly higher than that of the control group(P^0.05). After treatment, NIHSS scores of the two groups were significantly lower than those be- fore treatment (P〈O. 01), that of the observation group was significantly decreased (P〈0.05). Average middle cerebral ar- tery blood velocity (MCV) increased values were elevated after treatment, and that of the observation group increased more sig- nificantly (P〈0.05). After treatment, pulsatility index (PI) were significantly reduced, and that of the observation group sig- nificantly decreased (P〈0.05). After treatment, cerebral vascular reserve function (CVR) were significantly increased, and that of the observation group increased more significantly (P〈0.05). Conclusion Butylphthalide Injection can improve neuro- logical function and cerebrovascular reserve capacity in patients with acute cerebral infarction.
出处
《中国实用神经疾病杂志》
2014年第16期16-18,共3页
Chinese Journal of Practical Nervous Diseases
关键词
脑梗死
丁苯酞
神经功能
脑血管储备功能
Cerebral Infarction
Butylphthalide
Neurological Function
Cerebrovascular Reserve Capacity