降钙素原与内毒素在诊断腹部创伤术后患者肺部细菌感染的临床价值

Effect of procalcitonin and endotoxin in patients with pulmonary infection after abdominal trauma

目的研究降钙素原(PCT)与内毒素(ET)在腹部创伤术后患者肺部感染中的诊断价值。方法选择2005年1月—2012年5月腹部创伤术后肺部感染的患者140例,并根据肺部感染的病原体种类分为细菌组(44例)与非细菌组(96例),检测2组患者的血清PCT与ET水平。PCT<0.5 ng/ml为阴性,≥0.5ng/ml为阳性;ET<0.035 EU/ml为阴性,≥0.035 EU/ml为阳性。计算两者的诊断敏感度与特异度。结果细菌组PCT阳性率为90.91%(40/44),非细菌组阳性率为5.21%(5/96)。细菌组ET阳性率为68.18%(30/44),非细菌组阳性率为34.38%(33/96)。根据计算可知,PCT检测敏感度为90.91%(40/44),特异度为94.79%(91/96);ET检测敏感度为68.18%(30/44),特异度为65.62%(63/96)。2组比较差异均具有统计学意义(P<0.05)。结论降钙素原、内毒素检测对诊断腹部创伤术后患者肺部感染具有临床意义。

Objective To investigate the effect of procalcitonin （PCT） and endotoxin （ET） in abdominal trauma pa- tients with pulmonary infection. Methods From 2005 January to 2012 May, 140 patients of pulmonary＂ infection after abdomi- nal injury operation were enrolled, and according to the pathogenic species of pulmonary infection, they were divided into bac- terial infection group （44 cases） and non-bacterial infection group （96 cases）, serum PCT and ET levels were detected in the 2 groups of patient. PCT 〈0.5 ng/ml was defined as negative,PCT≥0.5 ng/ml was defined as positive; ET 〈0. 035 EU/ml was defined as negative, ET t〉 0. 035 EU/ml was defined as positive. Calculated the sensitivity and specificity of the two groups. Results Bacterial group g PCT positive rate of was 90.91% （40/44）, non-bacterial group g positive rate was 5.21% （5/96）. Bacteria groupg ET positive rate was 68.18% （30/44）, non-bacterial group′s positive rate was 34.38% （33/96）. According to the calculation, the PCT detection sensitivity was 90.91% （40/44）, the specificity was 94.79% （91/96） ; ET detection sensitivity was 68.18 % （30/44） , the specificity was 65.62% （63/96）. The differences between the 2 groups were statistically significant （ P 〈 0.05）. Conclusion It demonstrated that the detection of procalcitonin and endotoxin has clini- cal significance in the diagnosis of pulmonary infection in patients after abdominal trauma.