中药配方颗粒剂用于高脂血症的临床效果观察

Clinical Effect of Traditional Chinese Medicine Formula Granules on Hyperlipidemia

目的:分析观察对高脂血症采用中药配方颗粒剂临床治疗的效果。方法:攀枝花市第二人民医院内科2012年1月—2012年12月收治的58例高脂血症患者为研究对象,按照治疗方法不同分为常规组与血脂控制组(每组各29例)。常规组照常应用西药辛伐他汀(10 mg/次,晚间顿服)治疗,血脂控制组采用中药配方颗粒剂(山楂、水蛭、丹参)治疗,2组均接受为期1个月时间治疗,对比两组治疗前后临床治疗效果、血脂水平TC、TG、LDL-C。结果:常规组显效14例,有效10例,无效5例,治疗总有效率为82.76%;血脂控制组显效16例,有效9例,无效4例,治疗总有效率为86.21%,两组间数据比较(χ2=0.3436,t=0.5578,P>0.05)。常规组与血脂控制组治疗前后TC、Tg、LDL-C均有显著改善(P<0.05),血脂控制组血脂水平与常规组血脂水平比较无统计学意义(P>0.05)。结论:中药配方颗粒剂治疗高脂血症主要有途径广、靶点多、降血脂广谱、毒副作用小等优点,能够有效抑制脂类吸收,降低血脂水平。

Objective ： To analyze and observe the effect of clinical treatment on hyperlipemia by use of traditional Chinese medicine formula granules. Method ： Fifty-eight eases of hypedipidemia patients selected from the Second People＇s Hospital Sichuan Panzhihua from January 2012 to December 2012 were treated as research objects, and they were divided into the regular group and the blood lipid control group （ 29 cases in each group respectively ） according to different treatment methods. The patients in the regular group were treated with Simvastatin （ 10 mg/time, administered at draught at night ）, a western medicine, while the patients in the blood lipid control group were treated with traditional Chinese medicine formula granules （ hawthorn, leech, ~alvia miltiorrbiza ）. Patients in both groups were treated for 1 month, and clinical curative effect before and after treatment, blood lipid level, TC, TG and LDL-C of patients in both groups were compared. Restdts： 14 cases of patients with obvious effect, 10 cases with effective efficacy and 5 cases with effectiveness were found in the regular group, and the total effective rate of treatment was 82.76%, 16 cases with obvious efficacy,9 cases with effective efficacy and 4 case without efficacy were found in the blood lipid control group. The total effective rate was 86.21%, and the data comparison between two groups had no significance （ X 2=0-3436, t=0.5578, P〉0.05 ）. The TC, TG and LDL-C in the regular group and blood lipid control group before and after treatment were improved significantly （ P〈0.05 ）, and the lipid level of patients in the blood lipid control was of no statistical significance when it was compared to that of patients in the regular group （ P〉0.05 ）. Conclusion ： The traditional Chinese medicine formula granules in treating hyperlipidemia have advantages, such as promoting approach, substantial targets, extensive blood fat reduction, low side effect. This medicine can effectively inhibit lipid absorption and reduce blood fat level.