美沙拉嗪与柳氮磺胺吡啶治疗轻中度左半结肠型溃疡性结肠炎的疗效对比观察

The effects of mesalazine and sulfasalazine on mild to moderate left-sided ulcerative colitis

目的对比观察美沙拉嗪与柳氮磺胺吡啶治疗轻中度溃疡性结肠炎病人的疗效。方法采用随机对照研究方案,将入组的64例溃疡性结肠炎患者随机分为美沙拉嗪治疗组和柳氮磺胺吡啶治疗组,前者服用美沙拉嗪缓释颗粒剂,后者服用柳氮磺胺吡啶,疗程均为6周。记录治疗过程中出现的不良事件,根据改良Mayo评分系统评估两组治疗前后评分,判断治疗效果。结果美沙拉嗪治疗组有效率为90.6%,柳氮磺胺吡啶治疗组有效率为70.0%,两组有显著性差异(P<0.05);美沙拉嗪治疗组不良事件发生率显著低于柳氮磺胺吡啶治疗组。结论美沙拉嗪治疗轻中度左半结肠型溃疡性结肠炎疗效显著而又安全。

Objective To compare the effects of mesalazine and sulfasalazine for ulcerative colitis pa-tients. Methods patients with ulcerative colitis were randomly divided into treatment group and control group. Treatment group received mesalazine, and control group received sulfasalazine for a course of 6 weeks. The efficacy and adverse events of the two groups were observed. Results The total effective rate was 89.7.0%in treatment group which was significantly higher than 77.8%in control group （P〈0.05）. Adverse reaction rate was 5.1%in treatment group which was lower than 9.7%in control group, but the difference was not statisti-cally significant （P〉0.05）. Conclusion Sulfasalazine is effective in treatment of ulcerative colitis.