高尿酸血症与肾脏疾病

Hyperuricemia and kidney diseases

近年来，随着社会生活水平的提高，高尿酸血症（HUA）的患病率逐年升高，且与肾脏疾病、代谢性疾病及心血管疾病等密切相关。既往在儿童肾脏病疾患中对尿酸与肾脏病关系的认识及关注较少，相应的临床研究及诊治手段也有限，现就尿酸的代谢、HUA的病因和发病机制及其与肾脏疾病、药物之间的关系进行综述，提醒儿肾科医师关注高尿酸血症与肾脏疾病的关系。

The morbidity of hyperuricemia（HUA） has showed an increasing tendency in recent years, along with the improved social living conditions. HUA has been proved to be closely related to kidney diseases, metabolic diseases and cardiovascular diseases. However, people pay little attention to the relationship between uric acid and renal diseases in pediatrics, and the relevant studies and progress are lacking. Now a review is made about the metabolism of uric acid, the etiology and pathogenesis of HUA, and the relationship between HUA and kidney diseases or drugs,in order to pay attention to the relationship between HUA and kidney diseases.