摘要
扩张型心肌病(DCM)病因迄今不明,预后不良,无特异、有效的治疗方法,严重威胁人类的健康,故建立DCM动物模型,研究其发病机制和治疗疗效等必要而迫切。目前DCM的造模方法主要包括药物诱导、免疫诱导、分子生物学方法诱导等。本文就目前应用较为普遍、成熟的DCM模型的几种造模方法及其机理作一综述。
The cause of dilated cardiomyopthy （DCM） has not been elucidated yet .The poor prognosis and lack of specific and effective treatment became a serious health problem .Therefore to establish animal models of DCM to study the pathogenesis and treatment is necessary and urgent .At present the molding method of DCM mainly includes drug induction, immunological induction and molecular biology , etc.This article reviews the mature and commonly used establishing methods and mechanism of DCM models .
出处
《中国比较医学杂志》
CAS
2014年第8期47-52,共6页
Chinese Journal of Comparative Medicine
关键词
扩张型心肌病
造模
方法
机理
Dilated cardiomyopathy
Animal models
Molding,method
Mechanism
