奥美拉唑联合伊托必利治疗反流性食管炎的疗效及对生活质量的影响

Curative effect of omeprazole combined with itopride in the treatment of reflux esophagitis and its effect on life quality

目的观察奥美拉唑联合伊托必利治疗反流性食管炎的疗效及对生活质量的影响。方法选取2012年3月～2013年3月116例食管反流病患者,随机分为两组,对照组58例给予奥美拉唑治疗,观察组58例在对照组基础上给予伊托必利治疗,比较观察两组的症状变化、临床疗效、生活质量以及不良反应情况。结果两组治疗后烧心、反酸和胸骨后疼痛评分为（2.32±0.24）、（1.98±0.32）、（2.36±0.26）和（1.61±0.17）、（1.16±0.25）、（1.69±0.19）,与治疗前比较发生明显下降（t=4.012,3.984,4.223,6.231,5.982,7.014,P〈0.05）;观察组治疗后各评分明显低于对照组（t=3.992,4.013,4.114,P〈0.05）。观察组的痊愈率和总有效率分别为32.8%和91.4%,明显高于对照组的13.8%和72.4%（χ^2=5.841,7.036,P〈0.05）。观察组治疗后1个月、3个月和6个月生活质量评分均明显高于对照组（t=4.235,5.132,4.331,P〈0.05）。两组不良反应比较无统计学意义（χ^2=0.537,0.648,0.559,P〉0.05）。结论奥美拉唑联合伊托必利治疗反流性食管炎能够缓解临床症状,提高治疗效果,改善生活质量,并且不良反应少,值得临床推广应用。

Objective To observe the curative effect of omeprazole combined with itopride in the treatment of reflux esophagitis and its effect on life quality. Methods 116 patients with reflux esophagitis from March 2012 to March 2013 were randomly allocated to two groups.58 patients in the control group were given omeprazole,and another 58 patients in the control group were further given Itopride.Changes of symptoms, clinical effect,life quality and adverse events between the two group were observed and compared. Results Scores of heartburn,acid regurgitation and retrosternal pain in the two groups after the treatment were（2.32±0.24）,（1.98±0.32）,（2.36±0.26）and（1.61±0.17）,（1.16±0.25）,（1.69±0.19）respectively,significantly lower than those before the treatment（t=4.012,3.984,4.223,6.231,5.982,7.014,P〈0.05）;scores in the observation group after the treatment were significantly lower than those in the control group（t=3.992, 4.013,4.114,P〈0.05）.Recovery rate and total effective rate in the observation group were 32.8% and 91.4%, significantly higher than those of 13.8% and 72.4% in the control group（χ^2=5.841,7.036,P〈0.05）.Life quality in 1 month,3 months and 6 months after the treatment in the observation group were all significantly higher than those in the control group（t=4.235,5.132,4.331,P〈0.05）.Difference of adverse events between the two groups were not statistically significant（χ^2=0.537,0.648,0.559,P〈0.05）. Conclusion Omeprazole combined with itopride in the treatment of reflux esophagitis helps alleviate clinical symptoms,improve curative effect,enhance life quality and reduce adverse events,which is worthy of clinical promotion and application.