TACE联合MRI引导下射频消融术治疗原发性肝癌

TACE combined with MRI-guided radiofrequency ablation in treatment of primary hepatic carcinoma

目的探讨TACE联合MRI引导下射频消融(RFA)治疗原发性肝癌(PHC)的疗效。方法纳入接受TACE联合MRI引导下RFA的PHC患者50例(88个病灶),治疗后随访AFP水平及肿瘤复发情况。结果平均随访(15.35±8.49)个月。治疗后2个月,患者AFP水平为(33.94±11.64)μg/L,明显低于治疗前水平[(302.29±55.11)μg/L,P<0.01]。共9个治疗病灶复发,治疗后0.5年、1年、1.5年、2年和2.5年治疗病灶累积复发率分别为0、0、1.14%(1/88)、4.55%(4/88)和10.23%(9/88);共35例患者复发,治疗后0.5年、1年、1.5年、2年和2.5年总累积复发率分别为4.00%(2/50)、32.00%(16/50)、52.00%(26/50)、64.00%(32/50)和70.00%(35/50)。结论 TACE联合MRI引导下RFA治疗PHC创伤小、治疗病灶复发率相对较低,具有较高临床应用价值。

Objective To evaluate the efficacy of TACE combined with MRI-guided radiofrequency ablation（RFA）in treatment of primary hepatic carcinoma（PHC）.Methods A total of 50 patients with 88 lesions of PHC received TACE combined with MRI-guided RFA.The AFP level and the recurrence of PHC were assessed.Results The patients were followed up for（15.35±8.49）months.AFP level was（33.94±11.64）μg/L 2months after sequential operation,significantly lower than that before operation（[302.29±55.11]μg/L,P〈0.01）.PHC recurrence was noticed in 9primarily treated lesions,and the cumulative recurrence rate of primarily treated lesions was 0,0,1.14%（1/88）,4.55%（4/88）and 10.23%（9/88）for 0.5,1,1.5,2and 2.5years after combined therapy,respectively.PHC recurrence was found in35 patients,and the total cumulative recurrence rate was 4.00%（2/50）,32.00%（16/50）,52.00%（26/50）,64.00%（32/50）and 70.00%（35/50）for 0.5,1,1.5,2and 2.5years after combined therapy,respectively.Conclusion TACE combined with MRI-guided RFA is effective for treatment of PHC with small trauma and relative low recurrence,therefore having great clinical value.