沈阳市女性乳腺癌危险因素的病例对照研究

Case-control Study of Risk Factors of Breast Cancer in Shenyang

本文报告了150例女性乳腺癌病例和150名医院病人作对照,用条件Logistic回归模型进行乳腺癌危险因素的多变量分析。结果表明:精神创伤、性格(孤独、抑郁、焦虑、爱生闷气)、体重高、产次少、癌症家族史、闭经迟等均为乳腺癌的危险因素。经交互影响分析发现,精神创伤和性格(孤独、抑郁、焦虑、爱生闷气)、癌症家族史之间存在交互作用,OR值分别为2.854和3.475,p<0.01。

A hospital-based matched case-control study with 150 cases and 150 controls has been conducted from September, 1988 to December, 1989 in Shenyang city. The subjects were questioned about their reproductive history, history of benign breast diseases, menstruaus, family history of cancer, smoking habit, drinking habit, character, psychological injury, occupational stress, history of exposure of breast to x-ray before 18 years old and other factors. The results showed that psychological injury, character (depression, loneliness, anxiety, anguish), high weight, less parity, family history of cancer and late age at menopause were risk factors for breast cancer. The new discovery in the study was that there were interactions between psychological injury and character, and between psychological injury and family history of cancer. Odds ratios (OR) were 2.854 and 3.475, respectively.