甘精胰岛素联用阿卡波糖治疗老年糖尿病患者的临床疗效及安全性评价

Clinical curative effect and safety analysis of insulin glargine and acarbose treatment in elderly diabetes patients

目的评价甘精胰岛素联用阿卡波糖治疗老年糖尿病患者的临床疗效及安全性。方法老年糖尿病患者120例随机分为治疗组和对照组,各60例。治疗组用甘精胰岛素联合阿卡波糖,对照组用精蛋白生物合成人胰岛素注射液联合阿卡波糖,胰岛素始剂量为0.15 U·kg-1,根据血糖水平调整胰岛素用量及口服药物用量,随访观察3个月。监测患者血糖水平,并记录不良事件;随访记录2组患者的血糖达标时间和每日胰岛素总量,计算日平均血糖,检测患者治疗后的糖化血红蛋白水平和空腹C肽值。结果治疗3个月后,患者的糖化血红蛋白、空腹血糖及日平均血糖水平较治疗前均降低(P<0.05),其中,治疗组的日平均血糖水平显著低于对照组(P<0.05)。治疗组的血糖达标时间和胰岛素日用量均少于对照组(P均<0.05),治疗后空腹C肽含量明显高于对照组(P<0.05)。治疗组的不良反应发生率低于对照组(P<0.05)。结论甘精胰岛素联用阿卡波糖治疗老年糖尿病患者具有良好疗效,能快速、安全、有效地控制患者血糖。

Objective To study the clinical curative effect and safety analysis of insulin glargine with acarbose treatment in elderly patients with diabetes.Methods A total of 120 cases of elderly patients with diabetes were randomly divided into two groups.The 60 patients of treat-ment group were treated with insulin glargine and acarbose combination , and the 60 patients of the control group were treated with isophane prota -mine biosynthetic human insulin injection and acarbose combination .The patient monitored blood glucose levels and recorded adverse events .The therapeutic time and the daily amount of insulin were recorded of two groups of patients.The average daily blood sugar were calculated and the HbA1c and fasting c -peptide values were detected at 3 months after treatment.Results The HbA1c, fasting glucose, and daily average blood glucose levels were lower than before treatment .The average daily blood sugar level of treatment group was obviously lower than the control group.The therapeutic time of treatment group patients was lower than the control group patients and the dosage of insulinwaslower in treatment group than control patients usage.The nocturnal hypoglycemia and gas-trointestinal reaction event occurrences of the medicine were lower than the control group.The fasting c -peptide levels was higher than control group after treatment .Conclusion There was a good therapeutic effect for elderly diabetes patients with insulin combination and acarbose , which can fast safe and effective control blood sugar of patients.