幽门螺杆菌感染与支气管哮喘关系的meta分析

Relationship between Helicobacter Pylori Infection and Bronchial Asthma:a Meta-analysis

目的系统评价幽门螺杆菌感染与支气管哮喘之间关系。方法收集筛选研究幽门螺杆菌感染与支气管哮喘之间关系的文献,提取数据并进行定量综合分析。结果本次meta分析共纳入13篇文献,其中哮喘病例组3190例,对照组17 118例。支气管哮喘组与对照组中的幽门螺杆菌感染率存在显著差异,合并比值比为0.87(95%CI:0.80,0.95),P=0.001。亚洲人群中幽门螺杆菌感染与支气管哮喘风险的合并OR值为0.93(95%CI:0.75,1.16),P=0.530;欧美人群中幽门螺杆菌感染与支气管哮喘风险的合并OR值为0.86(95%CI 0.79,0.94),P=0.001。结论幽门螺杆菌感染可降低支气管哮喘发病率,临床上还需开展更多的研究来证实上述结论。

Objective To systematically evaluate the relationship between helicobacter pylori （ H. pylori） infec-tion and bronchial asthma. Methods Literature search was conducted to select the related publications on the relation-ship between H. pylori infection and bronchial asthma, and retrieval data was processed with quantitative meta-analysis. Results Thirteen studies were included in the meta-analysis, which included 3190 patients in bronchial asthma group and 17118 in control group. The H. pylori infection rate was significantly different between bronchial asthma group and control group, and the pooled odd ratio （OR） was 0. 87 （95%CI：0. 80-0. 95, P=0. 001）. The pooled ORs of H. pylo-ri infection and bronchial asthma risk were 0. 93 （95%CI：0. 75, 1. 16, P=0. 530） and 0. 86 （95%CI：0. 79, 0. 94, P=0. 001） in Asians and in European-American population respectively. Conclusion H. pylori infection may be asso-ciated with low risk of incidence rate of bronchial asthma, and further studies are needed to confirm the findings.