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牙髓细胞成牙本质分化的体外诱导:诱导因子及机制揭示 被引量:1

Odontoblastic differentiation of dental pulp cells in vitro: odontogenic stimuli and the underlying mechanisms
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摘要 背景:研究表明牙髓细胞在一定条件下经诱导可以向成牙本质细胞方向分化,该过程由信号网络调控。目的:综述牙髓细胞向成牙本质细胞方向分化的诱导因子及作用机制的研究进展。方法:应用计算机检索1998年1月至2014年7月中国知网(CNKI)和万方数据库相关文献,检索词"牙髓细胞,成牙本质细胞分化"限定文献语言种类为中文。同时计算机检索同期PubMed数据库相关文献,检索词"dental pulp cells,odontoblastic differentiation",限定文献种类为英文。初检所得文献467篇。包括中文214篇,英文253篇。对于初检文献,阅读标题和摘要进行初筛,排除因研究目的与本研究无关者或内容重复性的研究,最终纳入63篇文章进行综述。结果与结论:不同的诱导因子可以作为调控器,文章系统归纳了牙髓细胞在不同的诱导因子作用下,例如:骨形态发生蛋白、β-甘油磷酸钠、抗坏血酸及多种生长因子等,通过相关信号通路信号转导在一定程度上参与牙髓细胞向成牙本质细胞分化定向诱导。但成牙本质细胞分化是一个复杂的过程,进一步从细胞及分子水平研究成牙本质分化诱导因子及相关机制对于牙齿再生治疗临床应用具有重要意义。 BACKGROUND:Studies have shown that dental pulp cells can differentiate into odontoblastic like cells under certain stimulations, which is regulated by several signal pathways network. OBJECTIVE:To summarize the research progress of stimulating molecules and underlying molecular mechanisms of dental pulp cells’ odontoblastic differentiation. METHODS:A computer-based online search of CNKI and Wanfang databases was undertaken for the related Chinese articles dated from January 1998 to July 2014 with the keywords of“dental pulp cells”and“odontoblastic differentiation”in Chinese. Meanwhile, PubMed database was searched for the related English articles dated from January 1998 to July 2014 with the same keywords in English. Those with unrelated research subjects, or repetitive studies were excluded. Final y, 63 articles were reviewed. RESULTS AND CONCLUSION:Various stimuli, including bone morphogenetic protein,β-glycerophosphate and ascorbic acid, can stimulate dental pulp cells differentiation into odontoblastic like cells under certain conditions regulated by several signal pathways network. But odontoblastic differentiation is a complex process, and further research into stimulating molecules and underlying molecular mechanisms of dental pulp cells’ odontoblastic differentiation is significantly important for clinical applications of dental regenerative therapy.
出处 《中国组织工程研究》 CAS CSCD 2014年第37期6051-6058,共8页 Chinese Journal of Tissue Engineering Research
基金 天津市卫生局科技基金资助项目(2012KY19)~~
关键词 干细胞 诱导 牙髓细胞 成牙本质细胞分化 信号转导 dental pulp odontoblasts signal transduction
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