卒中后抑郁伴高同型半胱氨酸血症研究

Research on post-stroke depression with hyperhomocysteinemia

脑卒中患者的1/3发展为卒中后抑郁(post-stroke depression,PSD)。PSD加剧了脑卒中所带来的负面影响,增加了病死率,减缓了神经功能的恢复时间,削弱了恢复程度。目前研究表明高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)与普通人群中的脑卒中的发生具有相关性,但其与PSD的发生尚未明确。近年来,有关二者之间各方面的相关性研究较多(如流行病学、病理生理学机制、临床表现、诊断评估及药物治疗等),引起了广泛关注。

One third of all stroke survivors develop post-stroke depression（PSD）. It’s negatively impacts stroke outcome with increased morbidity, mortality and poorer functional recovery. Accumulating data suggest that hyperhomocysteinemia（HHcy） be associated with the risk of stroke in the general population, but the relationship remains unclear in PSD patients. In recent years, there have been a lot of studies on the correlation between them in many aspects （such as epidemiology, pathophysiology, clinical manifestation, diagnosis, and biological treatment）, which has aroused wide concern.