摘要
目的探讨羟苯磺酸钙联合替米沙坦治疗2型糖尿病肾病的临床疗效。方法将72例2型糖尿病肾病Ⅲ期患者按随机数字表法分为观察组和对照组,各36例。两组患者均给予胰岛素有效控制血糖,观察组给予羟苯磺酸钙500mg联合替米沙坦80mg治疗;对照组给予替米沙坦80mg治疗,疗程12周,观察并比较两组患者治疗前后尿蛋白、尿白蛋白排出率(UAER)、空腹血糖(FPG)、餐后2h血糖(PBS)、糖化血红蛋白(HbA_1c)、尿素氮(BUN)、肌酐(Cr)的变化。结果治疗12周后,两组患者尿蛋白、UAER水平均较治疗前明显下降(均P<0.05),且观察组患者低于对照组,差异均有统计学意义(均P<0.05);两组患者FPG、PBS、HbA_1c、BUN、Cr水平比较,差异均无统计学意义(均P>0.05)。结论羟苯磺酸钙联合替米沙坦治疗2型糖尿病肾病患者,较单用替米沙坦治疗更能有效地控制蛋白尿,值得临床应用。
Objective To evaluate the efficacy of calcium dobesilate combined with telmisartan in treatment of type 2 diabetic nephropathy. Methods Seventy two patients with type 2 diabetic nephropathy stage III were randomly divided into two groups: observation group (36 cases) treated with combination of calcium dobesilate and telmisartan; control group (36 cases) treated with telmisartan alone. Blood sugar was control ed by insulin effectively in both groups with fasting plasma glu-cose(FPG)〈8mmol·l^-1, postprandial blood sugar(PBS)〈10mmol/L. Urinary protein, UAER, FPG, PBS, HbA1c, BUN and CR of two groups were tested and compared before and after 12 weeks of treatment. Results Urinary albumin, UREA levels were lower in observation group than those in control group (P〈0.05), while there were no significant differences in FPG, PBS, HbA1c, BUN and CR levels between two groups (P〉0.05). Conclusion Compared with monotherapy of telmisartan, the combination of calcium dobesilate with telmisartan is more effective in treatment type 2 diabetic nephropathy.
出处
《浙江医学》
CAS
2014年第19期1629-1631,共3页
Zhejiang Medical Journal
关键词
糖尿病肾病
羟苯磺酸钙
替米沙坦
治疗
Diabetic nephropathy
Calcium dobesilate
Telmisartan
Treatment