绒毛膜促性腺激素及其游离β亚单位对不良妊娠的诊断价值

Diagnostic value of β-HCG and fβ-HCG of adverse pregnancy

目的探讨β绒毛膜促性腺激素(β-HCG)及其游离β亚单位(fβ-HCG)在不良妊娠中的诊断价值。方法运用化学发光分析技术分别检测早期不良妊娠患者(先兆流产组、稽留流产组、异位妊娠组)及正常妊娠孕妇(对照组)的血清β-HCG、fβ-HCG、黄体酮水平,计算各组48h后β-HCG的倍增率,对结果进行分析。结果与先兆流产组相比较,稽留流产组和异位妊娠组的β-HCG、fβ-HCG、黄体酮水平及β-HCG倍增率差异均有统计学意义(P<0.05)。稽留流产组与异位妊娠组之间各指标差异则无统计学意义(P>0.05)。结论β-HCG和fβ-HCG水平变化可反映不良妊娠。

Objective To explore the diagnostic value ofβ-human chorionic gonadotropin（β-HCG）and its freeβ-subunit（fβ-HCG）of adverse pregnancy.Methods Chemiluminescence technique was used for the detection of serum levels ofβ-HCG,fβ-HCG and progesterone in women with early adverse pregnancy（threatened abortion group,missed abortion group and ectopic pregnancy group）and normal pregnant women（control group）,respectively.The 48 hdoubling rate ofβ-HCG of each group was calculated.And the results were analyzed.Results Comparing with threatened abortion group,there were significant differences in the levels ofβ-HCG,fβ-HCG,progesterone and doubling rate both of missed abortion group and ectopic pregnancy group（P〈0.05）.However,there was no difference in these indicators between missed abortion group and ectopic pregnancy group（P〉0.05）.Conclusion The changes ofβ-HCG and fβ-HCG can reflect adverse pregnancy.