宫腔镜电切术对慢性宫颈炎患者的疗效研究

Effect of transcervical resection of myoma on patients with chronic cervicitis

目的探讨宫腔镜电切术治疗慢性宫颈炎的临床疗效以及对患者血清炎症因子的影响,以期为临床治疗提供理论依据。方法将2011年2月-2013年2月间收治的120例慢性宫颈炎患者,随机分为实验组与对照组,每组60例。实验组患者给予宫腔镜电切术治疗;对照组给予激光术治疗。比较术后两组患者临床疗效、并发症发生率以及血清白介素-6（IL-6）、高敏C反应蛋白（hs-CRF）、肿瘤坏死因子（TNF-α）以及超氧化物歧化酶（SOD）水平。结果经治疗后,实验组患者的临床总有效率为91.7%,并发症发生率为10.0%;而对照组则为76.7%、30.0%,两组比较差异有统计学意义（P〈0.05）;实验组患者的IL-6、hs-CRF、TNF-α以及SOD分别为（31.91±5.18）pg/m L、（1.29±0.25）mg/m L、（0.62±0.15）ng/m L、（302.33±32.20）ng/m L;而对照组分别为（48.85±5.54）pg/m L、（1.92±0.21）mg/m L、（1.09±0.17）ng/m L、（385.03±20.94）ng/m L,两组比较,实验组各项指标均显著低于对照组（P〈0.05）。结论宫腔镜下电切术治疗慢性宫颈炎临床疗效显著,能够显著降低患者血清炎症因子水平,并发症发生率较少,值得进行临床推广。

Objective To investigate the effect of transcervica] resection of myoma in the treatment for chronic cervicitis in order to provide the theoretical basis for clinical treatment. Methods A total of 120 cases of chronic eervieitis were randomly divided into the experimental group and the control group, 60 cases in each group. The patients in the experimental group were given transcervical resection of myoma, while laser surgery for the control group. The clinical curative effect, complications occurrence rate and serum IL-6, hs-CRF, TNF-α and SOD level were compared after operation. Results After treatment, the clinical curative effect and the complications rate in the experimental group were 91.7% and 21.7% , respetively; those of the control group were 76.7% and 51.7% , respectively. The IL-6, hs-CRF, TNF-α and SOD in the experimental group were （31.91 ± 5.18 ） pg/mL, （ 1.29 ± 0.25 ） mg/mL, （0.62 ± 0.15 ） ng/mL, （302.33 ± 32.20 ） ng/mL, which were significantly lower than those in the control group [（48.85 ±5.54） pg/mL, （1.92±0.21） mg/mL, （1.09±0.17） ng/mL, （385.03 ± 20.94）ng/mL], showing a significant difference between two groups（P〈0.05）. Conclusion Transcervical resection of myoma was effective in treatment of chronic eervicitis, and could reduce the level of serum inflammatory factors and complications rate, which is worthy for promoting.