N,O-羧甲基壳聚糖/海藻酸钠水凝胶的制备、溶胀性和质构性能研究

Study on Preparation, Swelling Characteristics and TPA Properties of N, O-carboxymethyl Chitosan/Alginate Hydrogels

以Ca Cl2为交联剂制备NOCC/海藻酸钠混合水凝胶,研究NOCC与SAL质量比、Ca Cl2含量、交联p H值和NOCC取代度对水凝胶在p H 1.2、6.8和7.4溶液中溶胀性的影响,同时研究了NOCC取代度对NOCC∕SAL水凝胶质构性能的影响。试验结果表明,NOCC与SAL按1:3的质量比混合,保持总固形物含量为2%,Ca Cl2含量为1%、交联p H值为7时形成的水凝胶在p H 1.2溶液中溶胀率较小,而在p H 6.8溶液中的溶胀率最大。NOCC取代度对水凝胶的溶胀性和质构性能有显著影响,水凝胶在p H 6.8和p H 7.4溶液中的溶胀率均随着取代度的增加而增大,且在p H 6.8溶液中的溶胀率大于在p H 7.4中的溶胀率。取代度为1.1的NOCC/SAL水凝胶硬度最大。

In this paper, the preparation of Ca2＋-crosslinked NOCC/sodium alginate（SAL） hydrogel was studied and the effects of NOCC/SAL ratio, Ca Cl2 concentration, crosslinking p H and the degree of substitution of NOCC on the swelling ratios of the resultant hydrogels in p H 1.2, p H 6.8 and p H 7.4 solutions were investigated. This paper is meaningful for the application of NOCC/SAL hydrogel in intestine-targeted delivery of sensitive compounds. The results indicated that hydrogels yielded by reaction at NOCC/SAL ratio 1∶3, total solid concentration 2%, Ca Cl2 concentration 1% and p H 7 had the lowest swelling ratio at p H 1.2 and highest swelling rate at p H 6.8. The degree of substitution of NOCC significantly influenced the swelling and texture properties of the hydrogels. The swelling ratios of the hydrogels in p H 6.8and p H 7.4 solutions increased along the rise of degree of substitution of NOCC and the swelling ratio in p H 6.8 was higher than that at p H 7.4. The hydrogel prepared with NOCC of 1.1 degree of substitution exhibited the highest hardness.