妊高征患者血浆神经肽Y水平变化及与妊高征发病的相关性探讨

Changes of plasma npy level of patients with pregnancy-induced hypertension syndrome and their relevance with onset of pregnancy-induced hypertension syndrome

目的：探讨妊娠期高血压综合征（简称妊高征）患者血浆神经肽Y（NPY）水平的变化及其与妊高征发病的关系。方法：入选我院2013年6月~2014年6月收治的80例妊高征孕妇作为观察对象,分别于产前和产后检测NPY水平,并与同期26例健康孕妇作比较,将观察组80例妊高征孕妇按照病情程度分为轻度妊高征组32例,中度妊高征组28例和重度妊高征组20例,比较产前和产后NPY水平,分析NPY水平变化与妊高征发病的关系。结果：观察组产前NPY水平[（165.6±70.2）ng/L]显著高于对照组[（89.5±13.4）ng/L],产后[（89.3±14.5）ng/L]显著低于产前,差异均具有统计学意义（P均〈0.05）;轻度组产前NPY水平[（90.3±16.5）ng/L]显著低于中度组[（155.5±18.2）ng/L]和重度组[（240.2±30.8）ng/L],中度组也显著低于重度组,3组产后均显著低于产前,且轻度组产后[（80.7±12.0）ng/L]和中度组产后[（82.1±13.5）ng/L]均显著低于重度组[（130.4±32.2）ng/L],差异均具有统计学意义（P均〈0.05）。结论：妊高征患者产前NPY水平升高,并可预测妊高征的发生和发展。

Objective： To discuss changes of plasma NPY level of patients pregnancy-induced hypertension syndrome （PIHS） and their relevance with onset of PIHS. Method： A total of 80 patients with PIHS were chosen as research objects. NPY level was detected before and after delivery, and compared with those of 26 healthy pregnant women in the same period. All patients with PIHS were divided into mild PIHS group with 32 cases, moderate PIHS group with 28 cases and severe PIHS group with 20 eases according to illness degree. NPY level before and after delivery were compared and the relationship be- tween NPY level change and PIHS onset was analyzed. Results： NPY level before delivery of observation group was （165.6± 70.2） ng/L, significantly higher than that of control group [ （89.5±13.4） ng/L]. N PY level after delivery was （89.3 ±14.5） ng/L, significantly lower than that before delivery （both P〈0.05）. NPY level before delivery of mild PIHS group was （90.3 ±16.5） ng/L, significantly lower than that of moderate PIHS group [（155.5± 18.2） ng/L] and severe PIHS group[（240.2± 30.8） ng/L]. NPY of moderate PIHS group was significantly lower than severe PIHS group. NPY level of the 3 groups afterdelivery was all significantly decreased after delivery, and NPY level of mild PIHS group after delivery [（80.7± 12.0） ng/L] and moderate PIHS group after delivery [ （82.1 ± 13.5） ng/L]were both significantly lower than severe PIHS group [ （130.4 ± 32.2） ng/L] （all P〈0.05）. Conclusion： NPY level of patients with PIHS before delivery rises and it can be used to predict onset and progress of PIHS.