氧化型低密度脂蛋白促动脉硬化机制被引量：13

下载PDF

导出

摘要动脉粥样硬化（As）是一种复杂的炎症性疾病,主要症状为动脉壁增厚变硬,失去弹性及管腔狭小等。其伴随的病理特征主要为动脉某些部位内膜下脂质沉积,伴有平滑肌细胞和纤维基质成分的增殖,并逐步发展形成动脉硬化斑块。研究发现低密度脂蛋白（LDL）,尤其是氧化型低密度脂蛋白（ox-LDL）在As的发病形成过程中起着重要作用。

作者张谦李培华岳文峰冯文利阿拉坦高勒

机构地区巴彦淖尔市医院检验科内蒙古医科大学药学院中国医学科学院北京协和医学院血液学研究所实验血液学国家重点实验室内蒙古大学生命科学院

出处《国际检验医学杂志》 CAS 2015年第3期382-385,共4页 International Journal of Laboratory Medicine

基金高等学校博士学科点专项科研基金项目(20091501110001) 国家自然基金资助项目(31160184)

关键词氧化型低密度脂蛋白溶血磷脂酰胆碱溶血磷脂酸动脉粥样硬化

分类号 R543.5 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献18

1Tomkin GH. Atherosclerosis, diabetes and lipoproteins[J]. Expert Rev Cardiovasc Ther,2010,8(7) : 1015-1029.
2Wilck N,Fechner M,Dreger H,et al. Attenuation of early athero genesis in low-density lipoprotein receptor deficient mice by pro teasome inhibition[J]. Arterioscler Thromb Vase Biol, 2012,32 (6):1418 -1426.
3Steinberg D, Witztum Jl: Oxidized low-density lipoprotein and atherosclerosis[J]. Arterioscler Thromb Vase Biol,2010,30(12) : 2311-2316.
4Peluso I, Morabito G, Urban L,et al. Oxidalive stress in athero- sclerosis development: the central role of I.DL and oxidative burst [J]. Endocr Metab Immune Disord Drug Targets, 2012, 12(4): 351-360.
5Komachi M, Damirin A, Malchinkhuu E, et al. Signaling path- ways involved in DNA synthesis and migration in response to ly- sophosphatidie acid and low-density lipoprotein in coronary artery smooth muscle cells[J]. Vascul Pharmacol, 2009, 50(5/6): 178- 184.
6Chauffe RJ, Wilensky RL. Mohler ER 3rd. Recent developments with lipoprotein-associated phospholipasc A2 inhibitors [J]. Curr Atheroscler Rep. 2010, 12(1) :43-47.
7Fang I., Harkewicz R, Hartvigsen K. et al. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation[J]. J Biol Chem, 2010, 285(42) : 32343-32351.
8Park S,Kim JA,Choi S,et al. Superoxide is a potential culprit of caspase-3 dependent endothelial cell death induced by lysophos phatidyleholine[J].J Physiol Pharmaeol, 2010,61 (4) : 375-381.
9Viekers KC, Castro-Chavez F, MorrisettJD. Lyso-phosphatidyl- choline induces osteogenic gene expression and phenotype in vas- cular smooth muscle cells [J]. Atherosclerosis, 2010, 211(1): 122-129.
10Bot M,Boi I, Lopez-Vales R, et al. Atherosclerotic lesion pro- gression changes lysophosphatidic acid homeostasis to favor its ac- cumulation [J]. AmJ Pathol, 2010, 176(6): 3073-3084.