外用重组人酸性成纤维细胞生长因子在儿童烧伤及愈合不良创面中的疗效研究

The Study of the Clinical Effects of External Use of Recombinant Human Acidic Fibroblast Growth Factor (RhaFGF) on the Burn and Poor Healing Wound in Children

目的探讨外用冻干重组人酸性成纤维细胞生长因子(艾夫吉夫)在烧伤及愈合不良创面的疗效,探讨在组织修复中的作用机制。方法自2007年1月—2014年3月期间共收治II^III度烧伤病例189例(总面积10%以下176例),根据创伤部位、程度、面积等选取有可比性的合适病例,按随机分配原则,同一个病人烫伤创面分实验组和对照组,实验组创面消毒、冲洗处理后,予艾夫吉夫创面喷洒或者填塞,创面加优拓覆盖处理,对照组则不使用艾夫吉夫,单纯用优拓覆盖,观察两组创面愈合情况和时间。结果实验组创面分泌物少,辅料较对照组干燥,分泌物浸透纱布的层数为对照组的70%,创面相对较平坦,愈合时间提前(浅II度2 d,深II度或III度5 d),差异有统计学意义(P<0.05)。结论使用艾夫吉夫可以促进创面愈合,缩短创面愈合时间。

Objective To observe the clinical effects of lyophilized recombinant human acidic fibroblast growth factor（RhaFGF） on the burn and poor healing wounds and investigate the mechanism in tissue repair.Methods A total of 189 cases with II-III degree burns（176 cases with less than 10% total burn size） from January 2007 to March 2014 were treated.According to the wound site,burn degree and extent of burn,the appropriate cases with comparability were selected;and based on the randomly principle,the burn wounds of the same patients were divided into the experimental group and the control group.After the treatment of wound disinfection and washing,the wounds in the experimental group were spayed or packed by Rha FGF,then covered by Urgotul dressing,while the wounds in the control group were only covered by Urgotul dressing without using Rha FGF.The wound healing and healing time of the two groups were observed.Results Compared with the control group,the secretion of wounds in the experimental group was less,the number of gaze layers saturated by secretion was 70% of the control group,so the dressing was drier,the wound was relatively smoother,the healing time was shorter（the healing time of shallow II degree burn was shortened by 2days,and that of deep II or III degree burn was shortened by 5 days）,the differences were statistically significant（P〈0.05）.Conclusion Rha FGF can promote wound healing and shorten the wound healing time.