人免疫缺陷病毒及其亚型测定方法

Detection methods for human immunodeficiency virus(HIV)and its subtyps

人类免疫缺陷病毒(HIV)是获得性免疫缺陷综合征(AIDS)的病原体,由于其基因组的高度变异性,形成了众多具有相对独立基因序列特征的亚型。现就HIV-1基因的分子特征、HIV-1的基因亚型分类、近年来报告的几种HIV-1基因亚型的测定方法作一综述。

Human immunodeficiency virus （HIV） is the pathogene of acquired immune deficiency syndrome （AIDS）. For the high variability of its genome, it facilitates the formation of the current multitudinous subtypes with relatively independent characteristics of gene sequence. This paper mainly reviews the molecular characteristics, subtype classification of HIV-1, and the reported de- tection methods of several HIV-1 subtypes in the recent years.