期刊文献+

护肝中药“五田保肝液”急性毒性实验研究 被引量:5

Study on acute toxicity test of Wutian Hepatoprotective Liquid
下载PDF
导出
摘要 [目的]明确护肝中药"五田保肝液"的用药安全剂量范围,为临床用药安全提供实验依据。[方法]依据中药、天然药物急性毒性实验研究技术指导原则设计实验,观察小鼠急性毒性反应,并记录其死亡情况,确定急性毒性实验中五田保肝液半数致死量(LD50)或最大给药量。[结果]半数致死量实验中未测得LD50,最大给药量实验获得小鼠最大给药量折合生药228 g/(kg·d),相当于成人临床用药量的120倍。[结论]护肝中药"五田保肝液"急性毒性反应低,临床常用药物剂量安全可靠。 [Objective] Clear safety dose range of Wutian hepatoprotective liquid, to provide the experimental basis for the clinical medication safety. [Methods] On the basis of acute toxicity of natural drug testing technology guidelines for research design, to observe the acute toxicity in mice, and record the death, to determine the acute toxicity test of Wutian Hepatoprotective liquid median lethal dose (LD50) or the maximum dose. [Results] The median lethal LDso hadn' t been measured in the experiment, and the maximum dose of the experimental mice had maximum dose equivalent 228g/(kg d), equivalent to the adult clinical use of the drug 120 times. [Conclusion] The liver protecting medicine "Wutian Hepatoprotective liquid" has low acute toxicity reaction, commonly used in clinical drug safety.
出处 《天津中医药大学学报》 CAS 2015年第1期27-29,共3页 Journal of Tianjin University of Traditional Chinese Medicine
基金 天津市中医药管理局中医 中西医结合科研专项课题(13112) 天津市滨海新区卫生局医药卫生科技项目(2011BHKZ010)
关键词 五田保肝液 急性毒性实验 半数致死量实验 最大给药量实验 Wutian Hepatoprotective liquid acute toxicity test median lethal dose test the maximum dose test
  • 引文网络
  • 相关文献

参考文献18

二级参考文献122

共引文献252

同被引文献42

引证文献5

二级引证文献17

;
使用帮助 返回顶部