经颅直流电刺激的研究进展

Advance of Transcranial Direct Current Stimulation(review)

经颅直流电刺激是一种无创性大脑皮层刺激方法。本文简要回顾其起源和发展,着重综述其机制。目前观点认为,经颅直流电刺激可能通过改变皮层兴奋性、增加突触可塑性、影响皮质兴奋/抑制平衡、改变局部脑血流、调节局部皮层和脑网联系等途径发挥调节脑功能的作用。本文通过比较分析相关文献、总结研究结果,提出要取得理想的刺激效果,仍有待深入探讨的两个问题,即刺激参数的选择及经颅直流电刺激与任务执行的时间关系。

Transcranial direct current stimulation is one of the non-invasive brain-stimulation techniques. Based on the introduction of the origin and development, this article gave an overview of the mechanisms emphatically, the current view is that the transcranial direct current stimulation may exert effect on neuromodulation by changing cortical excitability, increasing synaptic plasticity, impacting cortical excitation/inhibition balance, altering regional cerebral blood flow, modulating the activity within and between different cortical networks. In this review, clinical studies and analysis findings were compared, and then 2 problems should be discussed for ideal effects： choice of stimulating parameters and timing of the stimulation in relation to task performance.