尿激酶与重组组织型纤溶酶原激活剂用于急性肺栓塞溶栓的价值比较

Comparison between Values of Urokinase and RT- PA in Thrombolytic Therapy of Acute Pulmonary Embolism

目的评估尿激酶(UK)与重组组织型纤溶酶原激活剂(RT-PA)在急性肺栓塞(APE)溶栓治疗中的临床应用价值。方法选取APE行溶栓治疗患者150例,按溶栓方法分为UK组和RT-PA组,各75例。UK组接受UK溶栓治疗,RT-PA组接受RT-PA溶栓治疗,观察并比较两组患者的临床疗效、肺动脉收缩压、动脉收缩压、动脉血氧分压和并发症情况。结果 RT-PA组和UK组总有效率分别为89.33%和76.00%,差异有统计学意义(P<0.05);RT-PA组患者溶栓后肺动脉收缩压、动脉收缩压、动脉血氧分压情况和并发症情况明显优于UK组(P<0.05)。结论 RT-PA可有效提高APE的临床疗效,改善患者溶栓治疗后肺动脉收缩压、动脉收缩压、动脉血氧分压状况,降低出血并发症的发生率。

Objective To evaluate the clinical application values of urokinase（ UK） and recombinant tissue plasminogen activator（ RT-PA） in the thrombolytic therapy of acute pulmonary embolism（ APE）. Methods 150 patients with APE undergoing the thrombolytic therapy were allocated to the UK group and the RT- PA group according to the thrombolytic methods,75 cases in each group. The UK group accepted the UK thrombolytic therapy,while the RT- PA group was given the RT- PA thrombolytic therapy. The clinical effects,pulmonary artery systolic pressure,systolic blood pressure,arterial oxygen partial pressure and the occurrence of complications after treatment were compared between the two groups. Results The total effective rate of the RT- PA group and the UK group were 89. 33%and 76. 00% respectively,the difference was statistically significant（ P〈 0. 05）; the RT- PA group was better than the UK group in the pulmonary artery systolic pressure,systolic blood pressure,arterial oxygen partial pressure and complications occurrence rate,the differences were statistically significant（ P〈 0. 05）. Conclusion RT- PA can effectively improve the curative efficacy of APE,improves the pulmonary artery systolic pressure,systolic blood pressure,arterial oxygen partial pressure after the thrombolytic therapy and reduces the occurrence rate of hemorrhage complication.