健脑补肾丸联合尼莫地平对血管性痴呆患者血液流变学和认知功能的影响

Effect of Jiannao Bushen Pill Combined with Nimodipine on Cognitive Function and Hemorheology Index in Elderly Patients with Vascular Dementia

目的:探讨健脑补肾丸联合尼莫地平治疗对血管性痴呆(vascular dementia,VD)老年患者的疗效及应用价值,为临床治疗VD提供相应依据。方法:收集2009年1月至2013年1月在本院收治的90例VD患者作为研究对象。随机分为对照组和观察组各45例,对照组在常规治疗基础上给予尼莫地平60 mg/次,3次/d;观察组在常规治疗上给予口服健脑补肾丸(15粒/次,2次/d)联合尼莫地平进行治疗。比较两组VD患者疗效,简易精神状态检查(MMSE)评分、血液流变学指标及炎症因子水平。结果:对照组45例VD患者,治疗有效率为77.8%;观察组45例,治疗有效率为95.6%,显著高于对照组,差异具有统计学意义(P<0.05)。两组VD患者MMSE评分,血液流变学指标,C反应蛋白(CRP)与白细胞介素-6(IL-6)水平较治疗前均有所改善,差异均具有统计学意义(P<0.05)。然而经过治疗后,观察组患者MMSE评分、血液流变学指标、CRP与IL-6水平较对照组改善更为显著,差异均具有统计学意义(P<0.05)。结论:健脑补肾丸联合尼莫地平治疗VD可显著改善患者认知功能、降低其血液流变学指标,获得显著疗效,这可能与对CRP与IL-6水平的改善有关,值得在临床上进一步深入探讨与推广应用。

Objective： The aim of this study was to investigate the clinical effect of Jiannao Bushen pill combined with nimodipine on cognitive function and hemorheology index in elderly patients with vascular dementia （VD） and provide clinical basis for VD therapy. Method： From 2009/1 to 2013/1 , we collected 90 VD cases in our hospital and divided them into 2 groups randomly, 45 cases in control group and 45 cases in observation group. The control group was treated with conventional treatment and nimodipine, while the observation group was treated with conventional therapy, and Jiannao Bushen pill combined with nimodipine. Clinical effects, the mini mental state examination （MMSE） score, hemorheology index, and the levels of inflammatory factors were observed and compared. Result： The observation group had a therapeutic efficiency ratio （TER） of 95.6.0% which was significantly higher than the control group （77.8%） （P 〈 0.05 ）. The MMSE score, hemorheology index, and the levels of inflammatory factors of the both groups all significantly improved after treatments. However, those of the observation group were better improved than those of the control group after treatments （P 〈 0.05 ）. Conclusion ： Jiannao Bushen pill combined with nimodipine for VD therapy is effective, which is worthy of study and further application in clinical treatment. Our study provided new evidence for clinical therapy of VD.