美托洛尔联合阿托伐他汀对颈动脉粥样硬化患者实验室检查指标和IMT的影响

Effect of Metoprolol Combined with Atorvastatin on the Laboratory Examination Indexes and IMT of Carotid Atherosclerosis Patients

目的:观察美托洛尔联合阿托伐他汀对颈动脉粥样硬化患者实验室检查指标和颈动脉内膜中层厚度(IMT)的影响。方法:选取120例颈动脉粥样硬化患者,随机均分为A组(采用琥珀酸美托洛尔缓释片常规治疗)、B组(采用阿托伐他汀钙片常规治疗)、C组(采用两种药物联合治疗),各组疗程均为24周。观察各组患者治疗前后甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平,纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、凝血酶时间(TT)和超敏C反应蛋白(hs-CRP)水平,以及IMTmax和斑块积分。结果:治疗后,A组患者TC、TG、LDL-C、HDL-C与本组治疗前比较,差异均无统计学意义(P>0.05),而B、C组患者与A组及本组治疗前比较均显著改善,差异有统计学意义(P<0.05);A组患者FIB、APTT、PT与本组治疗前比较,差异均无统计学意义(P>0.05),而B、C组患者与A组及本组治疗前比较显著改善,且C组患者FIB较B组改善更显著,差异均有统计学意义(P<0.05);各组患者hs-CRP均较本组治疗前显著改善,而B、C组患者较A组改善更显著,C组较B组改善更显著,差异均有统计学意义(P<0.05);各组患者IMTmax和斑块积分均较本组治疗前显著改善,而B、C组患者较A组改善更显著,C组IMTmax较B组改善更显著,差异均有统计学意义(P<0.05)。结论:相比单独用药,美托洛尔联合阿托伐他汀用于颈动脉粥样硬化,可更有效地改善患者相关实验室检查指标和IMT。

OBJECTIVE： To observe the effects of metoprolol combined with atorvastatin on laboratory examination indexes and carotid artery intima-media thickness （IMT） of carotid atherosclerosis patients. METHODS： 120 patients with carotid athero- sclerosis were randomly divided into group A （routine treatment with Metoprolol suceinate sustained-release tablets）, group B （routine treatment with Atorvastatin calcium tablets） and group C （with combination of 2 kinds of drugs）, the course was 24 weeks. The clinic data of before and after treatment in each group was observed, including triglyceride （TG）, total cholesterol （TC）, lev- els of low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C）, fibrinogen（FIB）, activated partial thromboplastin time （APTT）, prothrombin time （PT）, thrombin time （TT） and level of high-sensitivity C-reactive protein （hs-CRP）, IMTmax and plaque scores. RESULTS： Compared with before treatment, there were no significant differences among the TC, TG, LDL-C and HDL-C in group treatment A（P〉0.05）, and group B and group C were significantly improved, with significant difference （P〈0.05）. Compared with before treatment, there were no significant differences among the FIB, APTT and PT in group A （P〉0.05）, group B and group C were significantly improved, and FIB in group C was more significantly improved than group B, with significant difference （P〈0.05）. Compared with before treatment, the hs-CRP in each group was significantly improved, group B and group C was more significantly improved than group A, group C was more significantly improved than group B, with significant differences（P〈0.05）. Compared with before treatment, the IMTmax and plaque scores in each group were significantly improved, group B and group C were more significantly improved than group A,and IMTmax in group C was more significantly improved than group B, with significant differences（P〈0.05）. CONCLUSIONS： Compared with single drug, metoprolol combined with atorvastatin can more effectively improve the related laboratory examination indexes and IMT of carotid atherosclerosis patients.