绿僵菌非核糖体肽合成酶的生物信息学分析

Bioinformatics analysis on non-ribosomal peptide synthetase of metarhizium acridum

通过生物信息学的方法对绿僵菌非核糖体肽合成酶进行了分析.生物信息学分析表明:其一级结构并不保守;二级结构含有15个α螺旋结构、9个β折叠、多个无规则卷曲;三级结构可能有酰基激活酶、乙酰辅酶A绑定位点和腺苷一磷酸绑定位点结构域.三维建模表示在Swissmodel数据库中具有可靠的模型.理化性质分析表明其是稳定性的蛋白质.

We analysed non-ribosomal peptide synthetase with bioinformatics.Analysis of bioinformatics showed that the primary sequence is not conservative,the secondary structure has 15αhelixes,9βsheets,many random coils,the tertiary structure may have AMP motif,acyl-activating enzyme motif and CoA banding site motif.Three-dimensional modeling data base has reliable model.Physicochemical property showed that it is stable protein.