健脾法治疗大肠癌作用机制及临床应用

Application and mechanism of Jianpi method in treatment of colorectal cancer

目的总结归纳中医健脾法在治疗大肠癌中的临床应用及作用机制,进一步指导临床治疗。方法根据近10年国内公开发表的相关文献及研究,从中医对大肠癌脾虚证的认识、健脾法的临床应用、健脾法的作用机制3个方面进行综述。结果脾胃亏虚是大肠癌发病的主要病机之一,健脾法是治疗大肠癌的重要方法之一,可抑制肿瘤细胞增殖、抑制肿瘤细胞侵袭转移、抑制肿瘤血管新生、调控相关信号通路及基因、调节免疫功能等。结论临床应用健脾法可在一定程度上预防大肠癌的复发转移,有效延长患者生存期,改善患者生活质量。

Objective To summarize and generalize the clinical application and the mechanism of Jianpi method in the treat- ment of colorectal cancer, further guiding the clinical treatment. Methods According to the related literature and research published in recent 10 years, three aspects- the TCM understanding of spleen deficiency in colorectal cancer, the clinical application of Jianpi method in the treatment of colorectal cancer and the mechanism of Jianpi method are reviewed. Results Spleen and stomach deficiency is one of the main pathogenesis of colorectal cancer;jianpi method is one of the important methods in the treatment of colorectal cancer. Its mechanism mainly involves inhibiting the proliferation of tumor cells, in- hibiting invasion and metastasis of tumor cells, suppressing tumor angiogenesis, regulating related gene, some regulating signaling pathways and immune function, etc. Conclusion Jianpi method can prevent recurrence of colorectal cancer metastasis to extent, effectively prolong survival time and improve the quality of life.