绒毛膜羊膜炎与早产儿脑损伤的研究进展

Research Advance on Brain Injury of Preterm Infants with Chorioamnionitis

绒毛膜羊膜炎是早产的重要危险因素,与早产儿脑损伤关系密切。早产和围生期感染共同作用导致早产儿脑损伤。炎性细胞因子在早产儿脑损伤的发生机制中起着核心作用。而影像学检查是诊断早产儿脑损伤的重要手段。防治围生期感染,加强围生期保健是防治早产儿脑损伤的关键。抗炎性细胞因子药物有望在干预早产儿脑损伤过程中起重要作用。

Chorioamnionitis is a major risk factor of premature birth,closely related to brain injury of preterm infants. Premature birth and prenatal infection promote brain injury of preterm infants. Inflammatory cytokines play a key role in the mechanisms of brain injury of preterm infants. Imaging examinations are the key way to the diagnosis of the brain injury in preterm infants. Avoiding prenatal infection and strengthening prenatal care is crucial to prevent and cure brain injury in preterm infants. Pro- inflammatory cytokines are expected to play an important role in the intervention of the brain injury of preterm infants.