COOK促宫颈成熟球囊用于中期妊娠依沙吖啶引产术中的疗效观察

Clinical Observation of Terminating Mid-pregnancy by Intra-amniotic Injection of Ethacridine with Cook Cervical Ripening Balloon

目的探讨COOK促宫颈成熟球囊用于中期妊娠依沙吖啶引产术中的临床效果及安全性。方法收集2011年1月-2012年12月孕16~28周引产者74例,随机分为研究组和对照组。研究组35例采用依沙吖啶羊膜腔注射联合COOK促宫颈成熟球囊引产,对照组39例采用依沙吖啶羊膜腔注射引产,比较两组引产临床效果和安全性。结果研究组羊膜腔注射后至规律子宫收缩（宫缩）时间、规律宫缩至胎盘娩出时间和胎盘胎膜残留率分别为（29.68±4.17）h、（7.63±2.30）h和28.6%（10/35）,对照组分别为（33.60±5.38）h、（9.86±3.20）h和56.4%（22/39）,两组比较差异均有统计学意义（P〈0.05）;研究组引产出血量和引产成功率分别为（81.60±17.64）m L和100.0%（35/35）,对照组分别为（83.82±15.08）m L和94.9%（37/39）,差异无统计学意义（P〉0.05）。结论 COOK促宫颈成熟球囊在中期妊娠依沙吖啶引产术中可缩短引产时间、减少胎盘胎膜残留,减轻产妇痛苦,值得应用推广。

Objective To probe into the clinical effects of intra-amniotic injection of ethacridine with Cook cervical ripening balloon in terminating mid-pregnancy. Methods A total of 150 mid-pregnant women who required induction of labor from January 2011 to December 2012 were randomly divided into two groups： observation group（intraamniotic injection of ethacridine with Cook cervical ripening balloon） and control group（intra-amniotic injection of ethacridine）. Results The time of labor induction was obviously shorter in the observation group than the control group [the time from using ethacridine to contraction：（29.68±4.17） vs（33.60±5.38） hours, P 〈 0.05; total process：（7.63±2.30） vs（9.86±3.20） hours, P 〈 0.05], and the residual rate of placental membranes [28.6%（10/35） vs 56.4%（22/39）, P 〈 0.05] was significantly lower. But there was no signifficant dif erence in postpartum hemorrhage [（81.60±17.64） vs（83.82±15.08） m L, P 〉 0.05] and rate of success [100.0%（35/35） vs 94.9%（37/39）, P 〉 0.05]. Conclusion Terminating mid-pregnancy by intra-amniotic injection of ethacridine with Cook cervical ripening balloon has the advantages of shorter time and less pain, whicThdeserves clinical application widely.