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特发性膜性肾病患者肾组织M型磷脂酶A2受体和Nephrin的表达及其对预后的影响 被引量：12

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摘要 目的探讨M型磷脂酶A2受体(M-type phospholipase A2 receptor,PLA2R)与Nephrin在特发性膜性肾病(idiopathic membranous nephropathy,IMN)发病中的作用及对预后的影响。方法采用免疫组化Eli Vision法检测IMN及正常对照组中PLA2R及Nephrin的表达,应用Image Pro-Plus软件半定量分析并判断其对预后的影响。结果 IMN组织中Nephrin表达较对照组明显减低(P<0.01),而PLA2R表达升高(P<0.05),IMN中PLA2R与Nephrin表达量呈负相关(P<0.01),Nephrin表达与24 h尿蛋白定量呈负相关(P<0.01),PLA2R的表达量与尿蛋白定量无相关性。各预后组PLA2R及Nephrin相对表达量差异无统计学意义。结论PLA2R、Nephrin均表达于IMN肾小球毛细血管袢,二者表达量呈负相关。二者表达与患者预后无明显相关性,但存在PLA2R表达越高,患者完全缓解率越高的趋势。
作者 崔静 李文娜 娄景秋 齐栋 张燕
机构地区 青岛大学医学院附属烟台毓璜顶医院肾内科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2015年第3期333-335,共3页 Chinese Journal of Clinical and Experimental Pathology
基金 烟台市科技发展基金(2013WS209)
关键词 肾小球肾炎 膜性肾病 M型磷脂酶A2受体 NEPHRIN
分类号 R692.6 [医药卫生—泌尿科学]
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参考文献10

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共引文献494

同被引文献86

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引证文献12

二级引证文献92

临床与实验病理学杂志
2015年 第3期

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