仙元方凝胶直肠给药体外释药规律研究

Rectally administration of Xian Yuan Fang gel and drug release in vitro

目的比较仙元方提取液、加不同浓度冰片仙元复方温敏凝胶剂和不加冰片仙元复方温敏凝胶剂直肠给药体外释药规律,探讨其释药机制。方法采用离体直肠立式扩散池法,以总多糖和总黄酮含量为考察指标对仙元方提取液、加不同浓度冰片仙元方凝胶剂、不加冰片仙元方凝胶剂体外释药规律进行研究。结果仙元复方提取液、仙元复方温敏凝胶在6 h基本完全释药,所有样品中多糖和黄酮释放规律均符合Higuchi方程。释放百分率:加5%冰片凝胶剂>提取液>加2%冰片凝胶剂>加0.5%冰片凝胶剂>不加冰片制剂。结论仙元复方加2%冰片凝胶剂直肠给药体外释药速度及累积释药量显著高于不加冰片凝胶剂,且直肠给药具有缓慢释药特性,高效、安全、给药方便。

Objective To compare the regularity of rectally drug release in vitro of the xian yuan compound extract, different concentrations of borneol addition and no borneol of xian yuan fang thermo-sensitive gel, and to explore its release mechanism. Methods In vitro rectum vertical diffusion pool method was used and total polysaccharides and flavonoids were used as review indicators to analyze the regularity of the xian yuan fang extract, different concentrations of borneol addition and no borneol of xian yuan fang thermo-sensitive gel. Results Xian yuan compound extract and xianyuan compound thermosensitive gel release completely in 6 h. The releasing regularity of polysaccharides and flavonoids in the samples were all accorded to Higuchi equation. The releasing percentage of joining in 5% borneol gel 〉 joining in 2% bomeol gel 〉 joining in 0.5% bomeol gel 〉 no containing borneol. Conclusion The releasing speed and cumulative release dosage of joining in 2 % borneol gel were significsntly higher than those of no containing, and rectally administration can release drug slowly with high effectiveness, safety and convenient administration.