盆腔炎对女性性激素的影响及其与不孕症的关系

The effect of pelvic inflammatory disease on female sex hormone and its relationship with infertility

目的:探讨盆腔炎对女性性激素水平的影响,研究盆腔炎与不孕不育的关系。方法:76例女性不孕症合并盆腔炎患者设为观察组1,50例单纯女性不孕症设为观察组2,并以同期有生育史健康女性62例为对照组,比较三组性激素水平及炎性因子差异。结果:三组性激素水平FSH、T差异无统计学意义(P>0.05),观察组1与观察组2及对照组比较,观察组1 LH、PRL、E2、P出现升高差异有统计学意义(P<0.05),观察组2与对照组比较性激素6项差异均无统计学意义(P>0.05);三组炎性因子比较,观察组1TNF、IL-2均出现升高,与观察组2及对照组差异有统计学意义(P<0.05),观察组2与对照组TNF、IL-2差异无统计学意义(P>0.05);合并盆腔炎不孕症患者炎性因子TNF、IL-2与LH、PRL、E2、P均呈正相关,均有统计学意义(P<0.05)。结论:盆腔炎与不孕症关系密切。

Objectives： To investigate the effect of pelvic inflammatory diseases on female sex hormone levels and the relationship between pelvic inflammatory disease and infertility. Methods： 76 female patients with infertility combined pelvic inflammatory disease were selected as observation group 1; 50 cases of simple female infertility were selected as observation group 2,and 62 healthy women with birth history at the same time were selected as control group. The sex hormone levels and inflammatory factors of the three groups were compared. Results： Difference in sex hormone levels of FSH,T among the three groups was not statistically significant（ P〉 0. 05）. Compared with control group,the increase in LH,PRL,E2,P of observation group 1 was statistically significant（ P〈 0. 05）,while those of observation group 2 was of no statistical significance（ P〉 0. 05）. As to the inflammatory factors,TNF,IL- 2 observation group 1 increased significantly,with statistically significant difference from observation group 2 and control group（ P〈 0. 05）; difference in TNF,IL- 2 between the observation group and the control group 2 was no statistically significant（ P〉 0. 05）. For patients with pelvic infection and infertility,inflammatory factor TNF,IL- 2 and LH,PRL,E2 and P were positively correlated,with statistical significance（ P〈 0. 05）.Conclusion： Pelvic inflammatory disease has close relationship with infertility.