骨保护素和胰岛素样生长因子在冠心病心力衰竭表达意义

目的探讨冠心病(congenital heart disease,CHD)心力衰竭患者血清中骨保护素(osteoprotegerin,OPG)和胰岛素样生长因子(insulin-like growth factor-I,IGF-I)的水平变化及其意义。方法采用酶联免疫吸附检测法测定116例CHD慢性心力衰竭患者(CHF组)和44例正常体检者(对照组)血清中OPG与IGF-I水平,进行对照分析。结果 CHF组患者血清OPG水平显著高于正常对照组(68.94±12.08)pg/m L,且随着心功能的恶化而显著增高(P<0.01);血清IGF-水平显著低于正常对照组(118.80±35.19)pg/m L,且随着心功能的恶化而显著降低(P<0.01)。血清中OPG与IGF-I水平呈负相关(r=-0.625,P<0.01)。结论 OPG与IGF-I共同参与了冠心病的心力衰竭的发生发展过程,二者的血清水平可以作为判断心力衰竭严重程度的指标。

ObjectiveTo explore the changes and significance of serum levels of osteoprotegerin （OPG） and insulin-like growth factor-Ⅰ（IGF-I） in patients with chronic heart failure（CHF） and coronary heart dis-ease（CHD）.MethodsEnzyme-linked immunosorbentassay（ELISA） was used to determine serum levels of OPGand IGF-I in 116 patients with CHFand CHD and 44 healthy subjects.Comparative analysis was taken. ResultsSerum OPGin CHFgroup was obviously higher than that in normal control groups（68.94±12.08）pg/mL,and increased with the deterioration of cardiac function obviously （P〈0.01）.Serum IGF-Iin CHFgroup was obviously lower than that in normal control group（118.80±35.19）pg/mL,and decreased with deterioration of cardiac function obviously （P〈0.01）.Serum OPG was negatively related with IGF-I（r=-0.625,P〈0.01）. ConclusionOPGand IGF-I conjointly participate in the occurrence and development of CHD and heart failure.Serum levels of OPGand IGF-I can be used as the indicators for assessing the severity of heart failure.