摘要
目的 1例再生障碍性贫血女性患者造血干细胞移植术后环孢素A的个体化给药剂量调整。方法持续的血药浓度监测,分析药物相互作用,调整口服给药剂量,使维持在合理治疗浓度范围。结果针对该例患者,环孢素A谷浓度控制在90~160 ng·ml-1范围内是安全有效的。结论通过药物代谢影响因素分析和制定环孢素A个体化给药方案,对于提高器官移植成功率,降低药物不良反应具有重要的临床意义。
Objective To regulate the personal dosage of cyclosporin A after haemopoietic stem cell transplantation due to aplastic anemia in a female patient.Methods Oral administration dosage was regulated by persistent monitoring of drug concentration and analyzing drug-drug interactions in order to obtain a rational therapeutic concentration range.Results The whole blood concentration of cyclosporin A that ranged from 90 to 160 ng·ml-1was clinically effective and safe in this patient.Conclusion Analysis and formulation of a personalized administration plan of cyclosporin A according to factors of drug metabolism can be very important for improving the success rate of organ transplantation and reducing adverse drug reactions.
出处
《解放军药学学报》
CAS
2014年第6期579-580,共2页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
治疗药物浓度监测
环孢素A
个体化给药
therapeutic drug monitoring
cyclosporin A
personalized medication