急性腹泻患儿应用布拉氏酵母菌散剂前后细胞免疫功能指标水平变化及意义

Changes and Significance of Cellular Immune Function Index Levels in Children with Acute Diarrhea before and after Application of Saccharomyces Boulardii Sachets

目的:通过急性腹泻患儿服用布拉式酵母散剂,观察服用前后细胞免疫功能指标水平的变化情况及意义。方法:选取笔者所在医院2012年7月-2013年7月收治的200例急性腹泻患儿作为研究对象,按照随机数字表法将其分为观察组126例和对照组74例。观察组患儿在服用抗生素、蒙脱石散剂口服及补液的基础上加用布拉式酵母散剂进行治疗,对照组患儿仅服用抗生素、蒙脱石散剂口服及补液进行治疗,对两组的治疗效果、平均止泻时间进行对比分析,观察对细胞免疫功能指标水平的影响。结果:观察组患儿治疗后1个月的CD3、CD4和CD4/CD8均明显高于治疗前,CD8明显低于治疗前,差异均有统计学意义(P<0.05),而对照组治疗前后比较差异均无统计学意义(P>0.05)。观察组的显效率66.67%和总有效率94.44%均明显高于对照组的33.78%和81.08%,差异均有统计学意义(P<0.05)。观察组的平均止泻时间(2.5±0.6)d明显短于对照组的(4.6±0.5)d,差异有统计学意义(t=25.3693,P=0.0000)。结论:在常规治疗的基础上加用布拉式酵母散剂对急性腹泻患儿进行治疗,可以增强小儿的细胞免疫功能,减少大便的次数,值得临床推广应用。

Objective：To observe the changes and significance of cell immune function index levels in children with acute diarrhea before and after taking Saccharomyces Boulardii Sachets.Method：200 cases of children with acute diarrhea admitted to our hospital were selected as the research objects,they were divided into the observation group for 126 cases and the control group for 74 cases according to the random number table method.The observation group was given antibiotics,oral rehydration of Smectite Powder treatment with Saccharomyces Boulardii Sachets,the control group was only given antibiotics,oral rehydration therapy and Smectite Powder.The treatment effect,average time of diarrhea between the two groups were compared and analyzed,and the effects on changes of cellular immune function index level were observed.Result：The CD3,CD4 and CD4/CD8 of the observation group after 1 month of treatment were significantly higher than the control group,the CD8 was significantly lower than the control group,the differences were statistically significant（P〈0.05）,the difference was not statistically significant before and after treatment in the control group（P〉0.05）.The significant efficiency and total effective rate of the observation group were 66.67%and 94.44%,which were significantly higher than 33.78%and 81.08%of the control group,the differences were statistically significant（P〈0.05）.The average time of diarrhea in the observation group was （2.5±0.6）d,which was significantly shorter than （4.6±0.5）d in the control group,the difference was statistically significant（t=25.3693,P=0.0000）.Conclusion：On the basis of conventional treatment combined with Saccharomyces Boulardii Sachets in the treatment of children with acute diarrhea,can enhance the cellular immune function of children,reduce the number of bowel movements,is worthy of clinical application.