降钙素原监测在儿童感染性疾病中的研究进展

Research Progress of Procalcitonin Monitoring in Pediatric Infectious Diseases

对于儿科急性炎症的危重患儿,有时难以区分脓毒症和非感染性疾病,临床传统指标又常缺乏敏感性和特异性,但及时正确的诊断对于制订治疗方案、监测抗生素治疗效果和疾病预后判断非常重要。降钙素原(PCT)在体内外稳定性好,对于细菌感染尤其脓毒症,PCT具有高度的敏感性和特异性,目前已成为临床全身性细菌感染诊治过程中必不可少的检测项目之一,为早期积极干预和改善脓毒症的预后提供更好的技术支持。

For pediatric critically ill patients who are presented as acute inflammation, sepsis or non- infectious disease are sometimes difficult to be distinguished. Traditional clinical indexes are often lack of sensitivity and specificity, but timely and correct diagnosis is of great importance for formulating therapeutic schedule,monitoring the efficacy of antibiotic and disease prognosis. Procalcitanin（PCT） is stable in rive and in vitro, which has high specificity and sensitivity for bacterial infections, especially for sepsis. At pres- ent, PCT has become indispensable test item in the diagnosis and treatment of clinical systemic bacterial infection,which provides better technical support for early intervention and improving prognosis of sepsis.