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地佐辛、右美托咪定单独或复合用药减轻瑞芬太尼诱发患者术后痛觉过敏效果的比较 被引量:35

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摘要 瑞芬太尼作为超短效阿片类镇痛药已广泛用于临床麻醉.研究证实,术中输注瑞芬太尼可诱发术后痛觉过敏[1-2].痛觉过敏不仅能降低阿片药物的镇痛效果,还可导致全麻苏醒期躁动,影响预后.地佐辛为阿片受体混合激动-拮抗剂,通过对μ受体的部分拮抗作用减轻瑞芬太尼引起的术后痛觉过敏[3].右美托咪定是一种高选择性α2肾上腺素能受体激动剂,可通过抑制NR2B亚基酪氨酸磷酸化,调控脊髓背角NMDA受体活性,减轻瑞芬太尼引起的术后痛觉过敏[4].
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 2015年第2期245-246,共2页 Chinese Journal of Anesthesiology
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