青年冠心病患者临床危险因素分析

Study on the risk factors of young patients with coronary artery disease

目的探讨青年冠心病患者的临床危险因素,为冠心病（CHD）的早期预防提供依据。方法回顾性分析2012-06~2014-06就诊于山西医科大学第二临床医学院心内科行冠状动脉造影检查的年龄≤45岁的胸痛患者240例,根据冠脉造影结果将其分为冠心病组120例和非冠心病组120例。收集两组患者的临床资料,对其进行统计学分析。结果青年冠心病患者组男性、吸烟史、高血压、高血压药物治疗、冠心病家族史比例、ALT、AST、ALP、GGT、肌酐、尿酸水平均高于非冠心病组,而饮酒史比例、HDL、apo A水平均低于非冠心病组。Loigistic回归分析发现吸烟史、冠心病家族史、apo A水平下降是青年冠心病的主要危险因素。结论吸烟史、冠心病家族史、apo A水平下降是早发冠心病患者的主要危险因素,在青年冠心病早发中起重要作用。

Objective To investigate the risk factors of coronary artery disease（CAD） in young patients, and provide the evidences for the prevention of CAD. Methods A total of 240 young patients, aged ≤ 45 years, undergoing coronary angiography （CAG） , were classified to CAD group （n = 120） and non-CAD group（ n = 120） according to the results of CAG. The clinical data of all patients were collected and the risk factors were compared between CAD group and non-CAD group. Results Compared with non-CAD group, the proportions of male, smoking, hypertension, hypertensive medication, CAD family history, and the levels of alanine transaminase, aspar- tate transaminase, alkaline phosphatase, gamma glutamyl transpeptidase, uric acid creatinine increased in CAD group, while the levels of HDL and apoA,tbe proportion of drinking history decreased（ P 〈 0.05 ）. The logistic regression resuhs revealed that the major risk factors of young CAD were CAD family history, smoking and low apoA level. Conclusion The results suggest that CAD family histo- ry, smoking and low apoA level may be the major risk factors of young CAD.