英夫利西单抗联合甲氨蝶呤治疗活动性类风湿关节炎疗效分析

Active rheumatoid arthritis Efficacy of infliximab combined with methotrexate therapy

目的研究分析英夫利西单抗联合甲氨蝶呤治疗活动性类风湿关节炎的临床效果。方法选取2011年12月—2013年12月在该院收治的130例活动性类风湿关节炎患者作为研究对象,将所有患者随机分为对照组和观察组各65例,对照组患者给予甲氨蝶呤治疗,观察组患者在对照组基础上联合英夫利昔单抗治疗,观察两组患者的临床治疗效果及各项临床指标情况,并作对比分析。结果观察组的晨僵时间、疼痛消失时间、肿胀缓解时间明显少于对照组,两组对比差异有统计学意义(P<0.05);观察组治疗后的类风湿因子(RF)、血沉(ESR)、C-反应蛋白(CRP)等指标下降程度明显低于对照组,两组对比差异有统计学意义(P<0.05)。结论采用英夫利西单抗联合甲氨蝶呤治疗活动性类风湿关节炎具有较高的临床应用价值,能够有效缩短患者的晨僵时间、疼痛消失时间、肿胀缓解时间,改善患者的各项临床指标,值得临床大力推广。

Objective To study the clinical effects of infliximab combined with methotrexate in the treatment of active rheumatoid arthritis. Methods December 2011 to December 2013 in our hospital 130 patients with active rheumatoid arthritis patients as re-search subjects, all the patients were randomly divided into a control group and observation group, 65 cases in the control group were treated with A methotrexate treatment, observation group were combined infliximab treatment, clinical outcomes were ob-served and the clinical indicators in the control group on the basis of, and for comparative analysis. Results The duration of morn-ing stiffness of the observation group, the pain disappeared time, relieve swelling time was less than the control group, a significant difference between two groups （P〈0.05）, a statistically significant;rheumatoid factor in the observation group after treatment （RF）, erythrocyte sedimentation rate （ESR）, C-reactive protein （CRP） and other indicators of the degree of decline was significantly low-er than the control group, a significant difference between two groups （P 〈0.05）, with statistical significance. Conclusion The use of infliximab in combination with methotrexate treatment of active rheumatoid arthritis with high clinical value, can shorten the du-ration of morning stiffness in patients, the pain disappeared time, relieve swelling time, improve the patientˊs clinical indicators worthy promoting.