摘要
目的观察SCC-Ag在宫颈鳞癌新辅助化疗(neo-adjuvant chemtherapy,NACT)前后的表达变化,探讨SCC-Ag与宫颈鳞癌NACT之间的相关性及临床价值。方法采用化学发光法检测NACT宫颈鳞癌患者中不同阶段SCC-Ag的表达水平,探讨SCC-Ag与宫颈鳞癌NACT后患者近期疗效、治疗方案及手术时机选择、临床病理特征及预后的关系。结果宫颈鳞癌患者治疗前血清SCC-Ag水平与临床分期、局部病灶大小和有无淋巴结转移呈正相关,与年龄无关;SCC-Ag表达在NACT后明显降低,临床有效和无效病例中SCC-Ag的表达有差异。结论 SCC-Ag表达水平变化与NACT疗效显著相关,可作为宫颈鳞癌分期、疗效判断、治疗方案及手术时机选择和预后判断的参考指标。
Objective To observe the squamous cell carcinoma antigen （SCC- Ag ） expression before and after neo-adjuvant chemotherapy （NACT） in cervical squamous cell carcinoma, and to explore the relationship and significance of SCC- Ag and cervical squamous cell carcinoma. Methods To detect the expression level of SCC - Ag in patients with cervical squamous cell carcinoma at different stages after neo-adjuvant chemotherapy by chemical luminescence method. Results Serum SCC - Ag level in cervical squamous cell carcinoma patients was positively as- sociated with clinical stages, lymph node metastasis but had no relationship with age before treatment. SCC- Ag level decreased significantly after NACT and it was related to the effectiveness of NACT. Conclusion SCC - Ag and NACT curative effect is distinct related, and can be used as a maker for clinical stage, treatment effect, opera- tion time choice and prognosis iudgment.
出处
《中国妇产科临床杂志》
CSCD
北大核心
2015年第3期229-232,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
