脂肪变性肝切除术后肝再生的研究进展

Research progress on liver regeneration after partial hepa- tectomy of fatty liver disease

脂肪肝为各种代谢异常所致肝实质细胞变性.脂肪肝可增加肝脏手术并发症的发生率和病死率,降低肝移植受者存活率,是肝脏手术的独立危险因素.因此,研究脂肪变性肝切除术后肝再生,对临床安全实施肝切除手术具有一定的指导意义.本文回顾近年有关脂肪变性肝切除术后肝再生的相关文献,对脂肪肝如何影响肝再生及其相关机制进行了综述.

Fatty liver disease is a kind disease characterized by liver parenchyma cell degeneration caused by a variety of metabolic abnormalities.Fatty liver disease could be considered as a risk factor for partial hepatectomy,because it can not only increase intraoperative and postoperative morbidity and mortality,but also reduce the survival rate of liver transplant recipients.Therefore,this study focuses on the impact of fatty liver disease on liver regeneration after partial hepatectomy,which could guide the clinical strategy for the implementation of liver resection.This paper overviews the recent progress on the impact of fatty liver disease on liver regeneration after partial hepatectomy and the related mechanism.