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The therapeutic potential of mesenchymal stem cells in Alzheimer's disease:converging mechanisms 被引量:3

The therapeutic potential of mesenchymal stem cells in Alzheimer's disease:converging mechanisms
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摘要 Mesenchymal stem cells (MSCS) are pluripotent stem cells isolated from various tissues, but mostly from bone marrow, adipose tissue, and umbilical cord blood. Well known for their mesenchymal lineages differentiation (e.g., bone, cartilage and fat tissues), it was suggested that MSCs possess plasticity prop- erties enabling them to differentiate into non-mesenchymal lineages. Indeed, several protocols claimed for differentiating MSCs to neurons in vitro, but concern was raised for the ef- fectiveness and in vivo relevance of such differentiation. Thus, though their neurogenic differentiation properties are still in debate, they were nevertheless, suggested as candidates for treat- ing neurodegenerative disorders such as Parkinson's diseases, multiple sclerosis and Alzheimer's disease (AD). Mesenchymal stem cells (MSCS) are pluripotent stem cells isolated from various tissues, but mostly from bone marrow, adipose tissue, and umbilical cord blood. Well known for their mesenchymal lineages differentiation (e.g., bone, cartilage and fat tissues), it was suggested that MSCs possess plasticity prop- erties enabling them to differentiate into non-mesenchymal lineages. Indeed, several protocols claimed for differentiating MSCs to neurons in vitro, but concern was raised for the ef- fectiveness and in vivo relevance of such differentiation. Thus, though their neurogenic differentiation properties are still in debate, they were nevertheless, suggested as candidates for treat- ing neurodegenerative disorders such as Parkinson's diseases, multiple sclerosis and Alzheimer's disease (AD).
作者 Gadi Turgeman
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第5期698-699,共2页 中国神经再生研究(英文版)
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