微波辅助无溶剂合成3-三氟乙酰基香豆素类化合物

Microwave Assisted Solvent-Free Synthesis of 3-(Trifluoroacetyl)coumarins

以2-羟基-2-三氟甲基-2H-苯并吡喃-3-甲酸乙酯类化合物为原料,在微波辅助和无溶剂的条件下进行再成环反应,合成了一系列3-三氟乙酰基香豆素类化合物.该方法具有反应时间短、产率高（73%~88%）、操作简单和环境友好等优点.产物结构使用IR、NMR、HRMS和X射线单晶衍射仪进行确定.

A series of 3-（trifluoroacetyl）coumarins were synthesized by recyclization of ethyl-2-hydroxy-2-trifluoromethyl- 2H-chromene-3-carboxylates under microwave assisted solvent-free conditions. This method has the advantages of short reaction time, high yields （73%-88%）, easy operation and environmental friendliness. The synthesized compounds were characterized by IR, NMR, HRMS and X-ray studies.