丹参酮ⅡA对缺血性脑中风的神经保护作用研究进展

Research progress in the study of protective effect of tanshinone IIA on cerebral ischemic stroke

丹参是我国的传统中药,临床上用于治疗心脑血管疾病如冠心病、心绞痛等已有悠久的历史。丹参酮IIA是从丹参中提取的一种菲醌类衍生物,是丹参发挥药理作用的主要活性成分之一。近年来研究发现,丹参酮IIA在缺血性脑中风的动物模型中具有良好的神经保护作用,表现在抗炎、抗氧化、抗凋亡和抑制兴奋性氨基酸毒性等多个方面。本文综述了丹参酮IIA对缺血性脑中风的神经保护作用研究进展,为丹参酮IIA的临床应用和成药性研发提供更多的思路。

Danshen is one of the traditional Chinese herbal medicines and has a long history of being used clinically in the treatment of cardiovascular and cerebrovascular conditions such as coronary heart disease and angina pectoris. Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Danshen. It has been reported to be the major bioactive compound of Danshen and has diverse biological effects. Recent studies demonstrated that tanshinone IIA had neuroprotective effects on experimental ischemic stroke through its anti- inflammatory, anti-oxidant, anti-apoptosis effects and its inhibitory effect on excitatory amino acid toxicity. In this review, we summarized all the recent progresses on the protective effect of tanshinone IIA on cerebral ischemic stroke. Hopefully, this article will throw some light on further study and application of tanshinone IIA.