2002-2013年上海市浦东新区居民卵巢癌发病死亡趋势分析

Analysis on the morbidity and mortality of ovary cancer and trends among residents in Pudong New Area of Shanghai,2002-2013

目的分析上海市浦东新区卵巢癌患者发病死亡情况及其发展趋势,为制定卵巢癌防治策略提供参考。方法以2002-01-01-2013-12-31上海市浦东新区女性户籍居民为研究对象,按1985年世界女性标准人口和1982年中国女性标准人口计算卵巢癌标化发病率和死亡率,并应用Joinpoint线性回归分析率值的变化百分比（percent changes,PC）和年均变化百分比（annual percent change,APC）并进行趋势分析。结果 2002-2013年卵巢癌新发病1 455例,占同期全区女性恶性肿瘤的2.84%。女性世界标化发病率为5.70/10万人年,中国标化率为4.83/10万人年。浦东新区卵巢癌发病率逐年下降趋势明显（APC=-3.19%,z=3.184,P=0.009）,卵巢癌发病率在0~10岁（PC=51.89%,z=7.51,P〈0.001）和10~54岁时（PC=6.98%,z=9.07,P〈0.001）随年龄增加上升趋势明显,发病高峰位于55~59岁（17.36/10万人年）。2002-2013年卵巢癌死亡患者762例,占同期全区女性恶性肿瘤的2.51%。女性世界标化死亡率为2.54/10万人年,中国标化率为1.94/10万人年。浦东新区卵巢癌死亡率趋势平稳（APC=0,z=-0.03,P=0.998）,卵巢癌死亡率在0~45岁时随年龄增加上升趋势明显（PC=17.26%,z=8.78,P〈0.001）,45岁后随年龄增加死亡率升高,但上升趋势差异无统计学意义（PC=2.83%,z=1.29,P=0.21）,死亡高峰位于80~85岁（17.46/10万人年）。结论浦东新区卵巢癌死亡趋势平稳,发病率呈明显下降趋势。在卵巢癌防治工作中应重点关注中老年女性居民的卵巢健康,争取早诊早治,降低其发病率和死亡率。

OBJECTIVE To analyze the morbidity and mortality of ovary cancer among female residents in Pudong New Area of Shanghai and to provide a reference for the prevention and predicting the trends.METHODS The female residents of Pudong New Area in Shanghai were recruited in this study from 2002 to 2013.The mortalities in different groups were calculated and standardized（age-standardized rate,ASR）by the world female population of 1985 and the Chinese female population of 1982.The trends of ovary cancer percent changes（PC）and annual percent changes（APC）from2002to 2013 were analyzed by Join-point regression program.RESULTS The total of 1 455 ovary cancer cases diagnosed from 2002 to 2013accounted for 2.84% of the malignant tumors of women at the same period.The world ASR of incidence was 5.70 per 100 000person-year,and the China ASR was 4.83 per 100 000person-year.The morbidity has statistically significant downward trend（APC=-3.19%,z=3.184,P=0.009）,the peak of incidence rate was occurred between 55 and 59years old,and there were obvious upward trends in 2stages,includes aged 0to 10 years old（PC=51.89%,z=7.51,P〈0.001）and 10 to 50years old（PC=6.98%,z=9.07,P〈0.001）.The total of 762 ovary cancer patients dead between 2002 and 2013accounted for 2.51% of the malignant tumors of women at the same period.The world ASR（age-standardized rate）of mortality was 2.54 per 100 000person-year,and the China ASR was 1.94per100 000person-year.The mortality was steady（APC=0,z=-0.03,P=0.998）.The peak of death rate was between 80 and 85years old,and there were obviously upward trend in mortality rate in aged 0to 45 years old（PC=17.26%,z=8.78,P〈0.001）.CONCLUSIONS Mortality of ovary cancer in Pudong new area is steadly and its incidence has a statistically significant downward trend.We should ensure middle-aged women＇s health of ovary and strive for early detection of ovarian cancer to reduce its morbidity and mortality.