温针灸结合推拿对膝关节骨性关节炎患者血清骨保护素、降钙素及骨钙素的影响

Effect of warm acupuncture and massage on osteoprotegerin, bone Gla-protein and calcitonin in patients with knee osteoarthritis

目的观察温针灸结合推拿手法治疗膝关节骨性关节炎的疗效。方法将120例膝关节骨性关节炎患者随机分为治疗组和对照组,分别给予温针灸结合推拿手法和口服双氯芬酸钠片剂治疗,观察其疗效,并分析两组治疗前后血清骨保护素(OPG)、降钙素(CT)及骨钙素(BGP)的变化。结果治疗组有效率(96.7%)明显高于对照组(85.0%)。两组患者治疗后积分均较治疗前减少(P<0.05),且治疗组积分减少程度明显优于对照组(P<0.05)。治疗后两组患者血清OPG水平较治疗前明显升高(P<0.05),治疗后两组患者BGP较治疗前明显升高(P<0.05);HCT较前无明显变化。结论温针灸结合推拿手法治疗膝关节骨性关节炎疗效确切,无内服药副作用,有推广价值。

[Objective] To observe the clinical effect of warm acupuncture and massage on knee osteoarthritis. [ Method ] A total of 120 cases were randomly divided into treatment group （warm acupuncture and massage group） and control group （oral diclofenac sodium tablets group） for comparison, with 60 cases in each group. The changes of osteoprotegerin （OPG）, calcitonin （CT） and bone Gla-protein （BGP） before and after treatment in two groups were analysed. [Results] The effective rate of treatment group （96.7%） was sinificantly higher than that of control group （85.0%）. Compared with preoperation, the symtom scores in two groups were both decreased after treatment （P 〈 0.05）, and the decreasing extent in the treatment group was significantly superior to that in the control group （P 〈 0.05）. Among those patients treated with warm acupuncture and massage, significant elevations in the serum levels of OPG and BGP was observed （P 〈 0.05）; CT had no significant change. [ Conclusions ] The curative effect of warm acupuncture and massage is better than oral diclofenac sodium tablets in treating knee osteoarthritis.