化痰息风方对癫痫患者认知功能与生活质量的影响

The Effects of Eliminating Phlegm and Calming Wind Decoction on the Cognitive Function and Life Quality of Patients with Epilepsy

目的观察化痰息风方对癫痫患者认知功能和生活质量的影响。方法将符合纳入标准的60例癫痫患者按照1∶1随机分为治疗组和对照组,分别在治疗前和治疗6个月后进行生活质量调查及认知功能评定。认知功能评定工具包括简易智能量表(MMSE)及逻辑记忆测验(LMT),生活质量调查采用癫痫患者生活质量调查表-31(QOLIE-31)。结果 1)经6个月的治疗后,治疗组患者的MMSE评分显著提高(P<0.01),而对照组则无明显改善(P>0.05);治疗组MMSE评分提高率较对照组为高(P<0.05);在逻辑记忆测验中,治疗组患者的LM1及LM2评分均显著提高(P<0.01),对照组患者LM1及LM2评分均有下降趋势,其中LM2评分显著降低(P<0.01)。2)经6个月的治疗后,两组患者在精力、社会功能、发作担忧及生活质量总分诸方面的得分均明显提高(P<0.01),治疗组患者在情绪、认知、药物影响方面评分明显提高(P<0.01),而对照组在认知功能方面反而出现减退的趋势(P<0.05);治疗组患者在情绪、认知、药物影响及生活质量总分方面的改善较对照组明显(P<0.05)。结论化痰息风方可改善癫痫患者的认知功能并全面提高其生活质量。

Objective： To observe the effects of Eliminating Phlegm and Calming Wind Decoction on the cogni- tive function and life quality of patients with epilepsy. Methods： 60 patients with epilepsy,in accordance with the inclusive criteria, were randomly assigned into the treatment group and the control group equally. Patients in both groups were graded in the cognitive function and life quality before treatment and after 6-month treatment,re- spectively,and their scores would be compared by MMSE,LMT and QOLIE-31. Results： 1 ）After 6-month treat- ment,patients in the treatment group showed significant improvement in the scores of MMSE （P 〈 0.01）,while there was no obvious improvement on the scores of MMSE in the control group （P〉 0.05）. The increase rate of MMSE scores in the treatment group was significantly different from that of the control group （P 〈 0.05）. In the logical memory test,patients in the treatment group showed significant improvement in the scores of LM1 and LM2 （P〈 0.01 ）. Meanwhile,the significant decline in the scores of LM2 appeared among patients in the control group （P 〈 0.01 ）. 2）After 6 months of treatment, patients in both groups showed significant improvement in the scores of energy,social function,seizure worry and overall quality of life （P 〈 0.01）. The significant improvement in the scores of emotion,cognitive function and medication effects appeared among patients in the treatment group （P〈 0.01）. However,patients in the control group showed significant decline in the scores of cognitive function （P〈 0.05）. The improvement in the scores of emotion, cognitive function, medication effects and overall quality of life among patients in the treatment group was more obvious than that of the patients in the control group （P〈 0.05）. Conclusion： Eliminating Phlegm and Calming Wind decoction can improve the cognitive function and life quality of patients with epilepsy.